Doses - SULFACHLORPYRIDAZINE SODIUM

Cattle:

a) 88 - 110 mg/kg IV once to twice daily. (Upson 1988)
b) 30 mg/kg PO q8h (Burrows 1980)
c) For bronchopneumonia and fibrinous pneumonia: 33 - 50 mg/kg q12h (method ofadministration not specified) (Hjerpe 1986)
d) In calves for labeled indications: 33 - 49.5 mg/kg PO, or IV bid for 1-5 days; suggestinitiating therapy with intravenous preparation and then changing to oral if possible.(Package insert; Vetisulid®¯Solvay)

Swine:

a) In swine for labeled indications: 44 - 77 mg/kg PO per day (divide dose and give twice daily if treating individual animals) for 1-5 days (Package insert; Vetisulid®¯Solvay)

Birds:

For enteric bacterial infections:
a) Using the oral powder: Mix 1/4 teaspoonful per liter of water and use as only supply ofdrinking water for 5-10 days. May be effective for many E. coli enteric infections.(Clubb 1986)
b) Using the oral powder: Mix 3/4 teaspoonful per 2 quarts of water. Fairly effective forenteric infections, particularly E.coli. Reserved for clients who are unable to give othermedications by mouth or parenterally. (McDonald 1989)
Monitoring Parameters -

1) Clinical efficacy

2) Adverse effects
Client Information - To help reduce the possibility of crystalluria occurring, animals should havefree access to water; avoid dehydration.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Sulfachlorpyridazine Sodium Injection 215 mg/ml in 250 ml bottles; Vetisulid® Injection (Fort
Dodge); (OTC) Approved for use in nonlactating dairy cat le and beef cattle. Slaughterwithdrawal = 5 days for cattle.
Sulfachlorpyridazine Sodium Oral Boluses 2 g bottles of 50 or 100; Vetisulid® Bolus (Fort
Dodge); (OTC) Indicated for use in calves under one month of age. Slaughter withdrawal = 7days.
Sulfachlorpyridazine Sodium Oral Powder 54 grams per bottle; Vetisulid® Powder (Fort
Dodge); (OTC) Indicated for use in calves under one month of age and swine. Slaughterwithdrawal = 7 days for cattle and 4 days for swine.
Sulfachlorpyridazine Sodium Oral Suspension 50 mg/ml in 180 ml bottles; Vetisulid® Oral
Suspension (Fort Dodge); (OTC) Approved for use in swine. Slaughter withdrawal = 4 daysfor swine.
Human-Approved Products: None