SULFADIMETHOXINE
Chemistry - A long-acting sulfonamide, sulfadimethoxine occurs as an odorless or almost odorless, creamy white powder. It is very slightly soluble in water and slightly soluble in alcohol.
Information on the Pharmacology, Contraindications, Precautions, Reproductive Safety,
Adverse Effects, Warnings, Overdosage, Acute Toxicity, Drug Interactions,
Drug/Laboratory Interactions, Monitoring Parameters & Client Information for the sulfonamide agents can be found in the Sulfachlorpyridazine and the TMP/Sulfa monographs.
Sulfadimethoxine is also used in the treatment of coccidiosis in dogs although not approved for thisindication.
In horses, sulfadimethoxine injection is approved for the treatment of respiratory infections causedby Streptococcus equi.
In cat le, the drug is approved for treating shipping fever complex, calf diphtheria, bacterialpneumonia and foot rot caused by susceptible organisms.
In poultry, sulfadimethoxine is added to drinking water to treat coccidiosis, fowl cholera and infectious coryza.
L/kg in cattle and horses. The drug is also highly protein bound.
In most species, sulfadimethoxine is acetylated in the liver to acetylsulfadimethoxine and excretedunchanged in the liver. In dogs, the drug is not appreciably hepatically metabolized and renalexcretion is the basis for the majority of elimination of the drug. Sulfadimethoxine's longelimination half-lives are a result of its appreciable reabsorption in the renal tubules. Serum half-lives reported in various species are: swine (14 hours), sheep (15 hours) and horses (11.3 hours).
Storage, Stability, Compatibility
Unless otherwise instructed by the manufacturer, store sulfadimethoxine products at room temperature and protect from light. Sulfadimethoxine injectionshould be stored at room temperature (15-30°C). If crystals form due to exposure to cold temperatures, either warm the vial or store at room temperature for several days to resolubolize thedrug. Efficacy is not impaired by this process.Information on the Pharmacology, Contraindications, Precautions, Reproductive Safety,
Adverse Effects, Warnings, Overdosage, Acute Toxicity, Drug Interactions,
Drug/Laboratory Interactions, Monitoring Parameters & Client Information for the sulfonamide agents can be found in the Sulfachlorpyridazine and the TMP/Sulfa monographs.
Uses, Indications
Sulfadimethoxine injection and tablets are approved for use in dogs and catsfor respiratory, genitourinary, enteric and soft tissue infections caused by susceptible organisms.Sulfadimethoxine is also used in the treatment of coccidiosis in dogs although not approved for thisindication.
In horses, sulfadimethoxine injection is approved for the treatment of respiratory infections causedby Streptococcus equi.
In cat le, the drug is approved for treating shipping fever complex, calf diphtheria, bacterialpneumonia and foot rot caused by susceptible organisms.
In poultry, sulfadimethoxine is added to drinking water to treat coccidiosis, fowl cholera and infectious coryza.
Pharmacokinetics - SULFADIMETHOXINE
In dogs, cats, swine and sheep, sulfadimethoxine is reportedly readily absorbed and well distributed. Relative volumes of distribution range from 0.17 L/kg in sheep to 0.35L/kg in cattle and horses. The drug is also highly protein bound.
In most species, sulfadimethoxine is acetylated in the liver to acetylsulfadimethoxine and excretedunchanged in the liver. In dogs, the drug is not appreciably hepatically metabolized and renalexcretion is the basis for the majority of elimination of the drug. Sulfadimethoxine's longelimination half-lives are a result of its appreciable reabsorption in the renal tubules. Serum half-lives reported in various species are: swine (14 hours), sheep (15 hours) and horses (11.3 hours).