Doses - SULFADIMETHOXINE

Dogs:

For susceptible infections:
a) 25 mg/kg PO, IV, or IM once daily (Davis 1985), (Kirk 1989)
b) 100 mg/kg PO, IV or IM once daily (Upson 1988)
c) 55 mg/kg PO, or IV, or SQ initially, then 27.5 mg/kg once daily thereafter. (Packageinsert; Albon®¯Roche)
For coccidiosis:
a) 55 mg/kg PO initially on the first day of therapy, then 27.5 mg/kg PO once daily for 9days (Matz 1995)
b) 50 mg/kg once daily for the first day, then 25 mg/kg once daily for 14-20 days. Sulfasare coccidiostatic. It is important that supportive care, including fluids and good nutrition be maintained during therapy. (Cornelius and Roberson 1986)

Cats:

For susceptible infections:
a) 25 mg/kg PO, IV, or IM once daily (Davis 1985), (Kirk 1989)
b) 100 mg/kg PO, IV or IM once daily (Upson 1988)
c) 55 mg/kg PO, or IV, or SQ initially, then 27.5 mg/kg once daily thereafter. (Packageinsert; Albon®¯Roche)
For coccidiosis:
a) 50 mg/kg once daily for the first day, then 25 mg/kg once daily for 14-20 days. Sulfasare coccidiostatic. It is important that supportive care, including fluids and good nutrition be maintained during therapy. (Cornelius and Roberson 1986)

Cattle:

For susceptible infections:
a) 110 mg/kg PO or IV once daily (Upson 1988)
b) 55 mg/kg IV initially, then 27.5 mg/kg IV once daily. (Baggot 1983)
c) 110 mg/kg PO q24h (Burrows 1980)
d) 55 mg/kg PO or IV initially, then 27.5 mg/kg q24h. (Jenkins 1986)
e) 55 mg/kg IV or PO initially, then 27.5 mg/kg q24h IV or PO for up to 5 days. If usingsustained release boluses: 137.5 mg/kg PO every 4 days. (Package insert;
Albon®¯Roche)

Horses:

For susceptible infections:
a) 55 mg/kg PO or IV q12h (Upson 1988)
b) 55 mg/kg IV or PO initially, then 27.5 mg/kg q24h IV (Package insert;
Albon®¯Roche)
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Sulfadimethoxine Injection 400 mg/ml (40%) in 100 ml and 250 ml vials
Albon® (Pfizer); (Rx) Approved for use in dogs, cats, horses and cattle. Not to be used inhorses intended for food or calves to be processed for veal. Slaughter withdrawal = 5 days(cattle); milk withdrawal = 60 hours.
Sulfadimethoxine Oral Tablets 125 mg, 250 mg, 500 mg
Albon® (Pfizer), (Rx) Approved for use in dogs and cats.
Sulfadimethoxine Oral Suspension 50 mg/ml in 1 oz. and 16 oz. bottles
Albon® (Pfizer); (Rx) Approved for use in dogs and cats.
Sulfadimethoxine Oral Suspension 125 mg/ml 5% in 2 and 16 oz. bottles
Albon® (Pfizer) (Rx) Approved for use in dogs and cats.
Sulfadimethoxine Oral Boluses 5 g, & 15 g
Albon® (Pfizer); (OTC) Approved for use in cattle. Slaughter withdrawal = 7 days (cattle); milkwithdrawal = 60 hours.
Sulfadimethoxine Oral Boluses Sustained-Release 12.5 g
Albon® (Pfizer); (Rx) Approved for use in non-lactating cattle. Slaughter withdrawal = 21 days(cattle)
Sulfadimethoxine Soluble Powder 94.6 g/packet (for addition to drinking water)
Albon® (Pfizer); (OTC) Approved for use in dairy calves, dairy heifers, beef cattle, broiler andreplacement chickens only, and meat-producing turkeys. Slaughter withdrawal = 7 days(cattle); 5 days (poultry¯do not use in chickens over 16 weeks old or in turkeys over 24weeks old).
Sulfadimethoxine 12.5% Concentrated Solution (for addition to drinking water); Albon®(Pfizer); Generic (OTC) Approved for use in chickens, turkeys and cattle. Slaughter withdrawal = 7 days (cattle); 5 days (poultry¯do not use in chickens over 16 weeks old or inturkeys over 24 weeks old).
Human-Approved Products: None