Doses - SODIUM POLYSTYRENE SULFONATE

To hasten the drug's action and to prevent constipation, SPS is generally mixed with 70%sorbitol (3-4 ml per one gram of resin); shake well before using.

Dogs:

For hyperkalemia:
a) 2 grams of resin/kg of body weight (each gram should be suspended in 3-4 ml of water;or use commercially prepared suspension products) divided into 3 daily doses. If givenorally, give with a cathartic. Do not use a cathartic if using as a retention enema as itmust be in the colon for at least 30 minutes. To prepare a retention enema from thepowder: add 15 grams per 100 ml of a 1% methylcellulose solution or 10% dextrose. Ifhyperkalemia is severe: 3-4 times the normal amount of resin may be given. (Willard1986)
Monitoring Parameters - 1) Serum electrolytes (sodium, potassium (at least once a day), calcium, magnesium; 2) acid/base status, ECG, if warranted
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Sodium Polystyrene Sulfonate Powder for Suspension (for rectal or oral use) in 1 lb. jars;
Kayexalate® (Sanofi Winthrop), (Rx)
Sodium Polystyrene Sulfonate Suspension: 15 g/60 ml (sodium 1.5 g, 65 mEq) in 120, 480 mland UD 60 ml; 15 g/60 ml in 50, 120, 200, & 500 ml; SPS® (Carolina Medical Products Co);
Sodium Polystyrene Sulfonate (Roxane) (Rx)