Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.


To hasten the drug's action and to prevent constipation, SPS is generally mixed with 70%sorbitol (3-4 ml per one gram of resin); shake well before using.

Dogs: Dog

For hyperkalemia:
a) 2 grams of resin/kg of body weight (each gram should be suspended in 3-4 ml of water;or use commercially prepared suspension products) divided into 3 daily doses. If givenorally, give with a cathartic. Do not use a cathartic if using as a retention enema as itmust be in the colon for at least 30 minutes. To prepare a retention enema from thepowder: add 15 grams per 100 ml of a 1% methylcellulose solution or 10% dextrose. Ifhyperkalemia is severe: 3-4 times the normal amount of resin may be given. (Willard1986)
Monitoring Parameters - 1) Serum electrolytes (sodium, potassium (at least once a day), calcium, magnesium; 2) acid/base status, ECG, if warranted
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Sodium Polystyrene Sulfonate Powder for Suspension (for rectal or oral use) in 1 lb. jars;
Kayexalate® (Sanofi Winthrop), (Rx)
Sodium Polystyrene Sulfonate Suspension: 15 g/60 ml (sodium 1.5 g, 65 mEq) in 120, 480 mland UD 60 ml; 15 g/60 ml in 50, 120, 200, & 500 ml; SPS® (Carolina Medical Products Co);
Sodium Polystyrene Sulfonate (Roxane) (Rx)

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