Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

Doses - SPECTINOMYCIN HCL

Dogs: Dog

For susceptible infections:
a) 5.5 - 11 mg/kg q12h IM or 22 mg/kg PO q12h (for enteric infections; not absorbed). (Kirk 1989)
b) 5 - 10 mg/kg IM q12h. (Davis 1985)
c) For acute infectious gastroenteritis: 5 - 12 mg/kg IM q12h (DeNovo 1986)

Cats: Cat

For susceptible infections:
a) For acute infectious gastroenteritis: 5 - 12 mg/kg IM q12h (DeNovo 1986)

Cattle: Cattle

For susceptible infections:
a) For bronchopneumonia and fibrinous pneumonia: 33 mg/kg SQ q8h. Suggested withdrawal time is 60 days. (Hjerpe 1986)
b) 22 - 39.6 mg/kg/day IM divided tid (Upson 1988)

Horses: Horse

For susceptible infections:
a) 20 mg/kg IM tid (Robinson 1987)
b) For pneumonia: 20 mg/kg IM q8h; may cause local myositis. Insufficient data tocomment on use. (Beech 1987b)

Swine: Swine

For susceptible enteric infections:
a) 10 mg/kg PO q12h (Howard 1986)
b) For bacterial enteritis (white scours) in baby pigs associated with E.coli susceptible tospectinomycin: 50 mg/10 lbs of body weight PO bid for 3-5 days. (Label directions;
Spectam Scour-Halt®¯Ceva)
c) 10 mg/kg IM q12h (Baggot 1983)
Birds:a) For airsacculitis associated with M. meleagridis or chronic respiratory disease associated with E.coli in turkey poults (1-3 day old): Inject 0.1 ml (10 mg) SQ in the base of the neck.
For control and to lessen mortality due to infections from M. synoviae, S. typhimurium,
S. infantis, and E. coli in newly hatched chicks: Dilute injection with normal saline to aconcentration of 2.5 - 5 mg/0.2 ml and inject SQ. (Label directions; Spectam®
Injectable¯Ceva)
b) For prevention and control of chronic respiratory disease associated with mycoplasmagallisepticum in broilers: Add sufficient amount to drinking water to attain a finalconcentration of 2 g/gallon.
For infectious synovitis associated with Mycoplasma synoviae in broilers: Add sufficient amount to drinking water to attain a final concentration of 1 g/gallon.
For improved weight gain/feed efficiency in floor-raised broilers: Add sufficient amountto drinking water to attain a final concentration of 0.5 g/gallon. (Label directions;
Spectam® Water-Soluble¯Ceva)
Monitoring Parameters -
1) Clinical efficacy
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Spectinomycin Injection 100 mg/ml 500 ml vials; Spectam® Injectable (Rhone Merieux); (OTC)
Approved for use in turkey poults and newly hatched chicks.
Spectinomycin Water Soluble Concentrate 50% Powder in 128 g (64 g spectinomycin), 200 g(100 g spectinomycin), 1000 g (500 g spectinomycin) packets; Spectam® Water Soluble
Concentrate (Rhone Merieux); (OTC) Approved for use in chickens (not layers). Slaughterwithdrawal = 5 days.
Spectinomycin Oral Solution 50 mg/ml in 240 ml pump bottle and 500 and 1000 ml refill bottles; Spectam Scour-Halt® (Rhone Merieux); (OTC) Approved for use in swine (Not olderthan 4 weeks of age or greater than 15 lbs of b.w.). Slaughter w'drawal = 21 days.
Spectinomycin Oral Solution 50 mg/ml in 240 ml pump bottle and 500 and 1000 ml refill bottles; Spectinomycin Oral Liquid (Syntex); (OTC) Approved for use in swine (Not older than4 weeks of age or greater than 15 lbs of b.w.). Slaughter w'drawal = 21 days.
Spectinomycin combination products:
Spectinomycin/Lincomycin in a 2:1 ratio Soluble Powder
LS 50 Water Soluble Powder (Upjohn); (OTC) Approved for use in chickens. No withdrawal time required.

Human-Approved Products:

Spectinomycin Powder for Injection 400 mg (as the HCl) per ml after reconstitution. 2 g vialwith 3.2 ml diluent and 4 g vial with 6.2 ml diluent.; Trobicin® (Upjohn); (Rx)

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