Doses - HYDROCHLOROTHIAZIDE

Dogs:

For treatment of nephrogenic diabetes insipidus:
a) 0.5 - 1.0 mg/kg PO bid (Morgan 1988)
b) 2.5 - 5.0 mg/kg PO bid (Nichols 1989)
For treatment of systemic hypertension:
a) 2 - 4 mg/kg PO q12-24h with dietary salt restriction (Cowgill and Kallet 1986)
For treatment of recurrent calcium oxalate uroliths with renal hypercalcuria:
a) 2 mg/kg q12h PO. Note: Do not use in patients with absorptive (intestinal) hypercalcuria as hypercalcemia may result (Polzin and Osborne 1985)
As a diuretic:
a) 2 - 4 mg/kg PO once to twice daily (Morgan 1988)
For treatment of hypoglycemia (with diazoxide):
a) 2 - 4 mg/kg PO bid (Morgan 1988)

Cattle:

For udder edema:
a) 125 - 250 mg IV or IM once or twice a day; may continue for several days if necessary.
Consider switching to oral chlorothiazide after initial dose. (Package Insert - Hydrozide® Injection; MSD)
Client Information - Clients should contact veterinarian if symptoms of water or electrolyte imbalance occur. Symptoms such as excessive thirst, lethargy, lassitude, restlessness, oliguria, GI distress or tachycardia may indicate electrolyte or water balance problem.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Hydrochlorothiazide Veterinary Injection 25 mg/ml, 50 ml vial; Hydrozide® Injection (Rhone
Merieux); (Rx) Approved for use in cattle. There is a 72 hour milk-witholding time for lactating dairy cattle; no meat witholding time is listed.

Human-Approved Products:

Hydrochlorothiazide Tablets 25 mg, 50 mg, 100 mg; HydroDiuril® (Merck); Generic (Rx)
Hydrochlorothiazide Oral Solution 10 mg/ml in 500 ml bottles; Generic (Rx)
Fixed dose combinations of hydrochlorothiazide with: hydralazine, amiloride, propranolol, triamterene, captopril, reserpine, enalapril, guanethidine, metoprolol, spironolactone, timolol, methyldopa or labetolol are also available.