Doses - POLYSULFATED GLYCOSAMINOGLYCAN (PSGAG)

Horses:

a) For IM administration: 500 mg IM (of IM product) every 4 days for 28 days.
Thoroughly cleanse injection site before injecting. Do not mix with other drugs orchemicals. (Package Insert- Adequan® I.M.)
For intra-articular administration: 250 mg (of IA product) IA once a week for 5 weeks.
Joint area should be shaved, and cleansed as if a surgical procedure, prior to injecting.
Do not mix with other drugs or chemicals. (Package Insert- Adequan® I.M.)
b) For IM injection: 500 mg IM every 3-4 days for a minimum of 4 and preferably, 7treatments.
For intra-articular injection: As above; author recommends adding 125 mg of amikacinfor injection into the IA injection to reduce potential for infection. (Nixon 1992)

Dogs:

For the treatment of traumatic, degenerative or chronic aseptic joint disease:
a) 3 - 5 mg/kg IM every 3-5 days for 3 weeks (Bloomberg 1992)
b) 1.1 - 4.8 mg/kg IM every 4 days for six doses and then as needed. (Kelly 1995)

Cats:

As a chondroprotective drug:
a) 1.1 - 4.8 mg/kg IM every 4 days for six doses and then as needed. (Kelly 1995)
Monitoring Parameters - Efficacy and joint inflammation/infection if administered IA.
Client Information - The IA product must be administered by veterinary professionals; the IMproduct could, with proper instruction be administered by the owner.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Polysulfated glycosaminoglycan for Intra-Articular Injection 250 mg/ml in 1 ml glass ampulesor 1 ml single use vials, boxes of 6; Adequan® I.A. (Luitpold); (Rx) Approved for use inhorses (not in those intended for food).
Polysulfated glycosaminoglycan for Intra-Muscular Injection 100 mg/ml in 5 ml glass ampulesor 5 ml vials, boxes of 4; Adequan® I.M. (Luitpold); (Rx) Approved for use in horses (not inthose intended for food).
Polysulfated glycosaminoglycan for IM Injection 100 mg/ml; Adequan® Canine (Luitpold);(Rx) Approved for use in Dogs.
Human-Approved Products: None
Potassium Bromide - see Bromide Salts