Doses - NITROGLYCERIN, TOPICAL

Dogs:

a) 1/4 - 1 inch cutaneously every 6-8 hours (Bonagura and Muir 1986)
b) 1/4 - 2 inches topically tid-qid; 1/4 - 1/2 inch topically (inside ear) for small dogs; 2inches topically for giant breeds (Tilley and Owens 1985)

Cats:

a) 1/4 inch cutaneously every 6-8 hours (Bonagura and Muir 1986)
b) 1/8 - 1/4 inch topically tid (Tilley and Owens 1985)
Monitoring Parameters -

1) Clinical efficacy

2) Sites of application for rash symptoms

3) Blood pressure, if possible or if hypotensive effects are seen
Client Information - Dosage is measured in inches of ointment; use papers supplied with productto measure appropriate dose. Wear gloves (non-permeable) when applying. Do not pet animalwhere ointment has been applied. Rotate application sites. Recommended application sites include:groin, inside the ears, and thorax. Rub ointment into skin well. If rash develops, do not use that siteagain until cleared. Contact veterinarian if rash persists or animal's condition deteriorates. There isno danger of explosion or fire with the use of this product.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None
Human-Approved Products: Note: Many dosage forms of nitroglycerin are available for humanuse, including sublingual tablets, buccal tablets, lingual spray, extended-release oral capsules andtablets, transdermal patches, and parenteral solutions for IV infusion. Because the use ofnitroglycerin in small animal medicine is basically limited to the use of topical ointment, those otherdosage forms will not be included here.
Nitroglycerin Topical Ointment 2% in a lanolin-petrolatum base in 20, 30 and 60 gram tubes &
UD 1g & 3 g; Nitro-bid® (Hoechst Marion Roussel); Nitrol® (Savage); Generic; (Rx)