Doses - PENTOBARBITAL SODIUM

Dogs:

a) For adjunctive therapy for ulcerative dermatosis of Shelties and Collies: 400 mg (onetablet) PO once daily or every other day if vomiting is a problem. If it can be reformulatedinto capsules, divide daily dose and give up to 3 times daily. (Ihrke and Gross 1997)
b) For adjunctive treatment (with corticosteroids, vitamin E, etc) of dermatomyositis: 10mg/kg PO once a day to every other day. Give with food. May result in improvement in 2-3 months of tx. (Buerger 1997)
c) For adjunctive treatment of ear margin seborrhea: 400 mg (one tablet) PO per day; if dogweighs less than 10 kg: use 200 mg/day. (Rosychuck and Swartout 1997)

Horses:

a) To reduce the cytokine effects in endotoxemia: 8.5 mg/kg PO bid (considered to beexperimental therapy) (Edens and Cargile 1997)
b) For treatment of navicular disease: 6 grams per day PO for 6 weeks (Livesay 1996)
Monitoring Parameters - Efficacy and adverse effects
Client Information - To reduce the GI effects of pentoxifylline, give with food. Clients shouldunderstand that veterinary experience with this medication is limited and that the risk versus benefitprofile is not well defined.
Dosage Forms/Preparations/FDA Approval Status - Veterinary-Approved Products: None

Human-Approved Products:

Pentoxifylline 400 mg extended-release tablets (pink); Trental® Tablets (Hoechst Marion Roussel), Generic; (Rx)