Doses - YOHIMBINE HCL

Dogs:

For xylazine reversal:
a) 0.11 mg/kg IV slowly (Package insert; Yobine®¯Lloyd)
b) 0.1 mg/kg IV (Gross and Tranquilli 1989)
c) As an antiemetic: 0.25 - 0.5 mg/kg q12h subQ or IM (Washabau and Elie 1995)

Cats:

For xylazine reversal:
a) As an antiemetic: 0.25 - 0.5 mg/kg q12h subQ or IM (Washabau and Elie 1995)
Rabbits/Rodents/Pocket Pets:
To reverse the effects of xylazine and to partially antagonize the effects of ketamine andacepromazine: Rabbits: 0.2 mg/kg IV as needed; Mice/Rats: 0.2 mg/kg IP as needed(Huerkamp 1995)

Cattle:

For xylazine reversal:
a) 0.125 mg/kg IV (Gross and Tranquilli 1989)

Horses:

For xylazine reversal:
a) 0.075 mg/kg IV (Gross and Tranquilli 1989)
Llamas:
For xylazine reversal:
a) 0.25 mg/kg IV or IM (Fowler 1989)
Deer:
For xylazine reversal:
a) In wild, exotic and ranched deer: 0.2 - 0.3 mg/kg IV (Package Insert¯Antagonil® - Wildlife Labs)
Note: Yohimbine has also been used as a reversal agent in several exotic species. Severaldosages are listed in the chapter on Stimulants by Booth in Veterinary Pharmacologyand Therapeutics, 6th Edition. Booth, NH & McDonald, LE Eds., Iowa State University
Press. Ames. 1988
Monitoring Parameters -

1) CNS status (arousal level, etc.)

2) Cardiac rate; rhythm (if indicated), blood pressure (if indicated and practical)

3) Respiratory rate
Client Information - This agent should be used with direct professional supervision only.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Yohimbine Sterile Solution for Injection 2 mg/ml in 20 ml vials Yobine® (Lloyd); (Rx)
Approved for use in dogs.
Yohimbine HCl Sterile Solution for Injection 5 mg/ml in 20 ml vials; Antagonil® (Wildlife
Labs); (Rx) Approved for use in deer.
Human-Approved Products: Oral 5.4 mg tablets are available, but would unlikely to be ofveterinary benefit.
Zolazepam - see Tiletamine/Zolazepam