Doses - ATIPAMEZOLE HCL

Dogs:

For reversal of medetomidine:
a) Give IM an equal volume of Antisedan® as Domitor® is administered (ml per ml). Theactual concentration of Antisedan® will be 5X that of Domitor®, as Antisedan® is 5mg/ml versus Domitor®'s 1 mg/ml. (Package Insert; Antisedan®¯Pfizer)
b) As above, but may give IV as well as IM. If it has been at least 45 minutes sincemedetomidine was given, may give atipamezole at half the volume of medetomidine ifadministered IV. If after 10-15 minutes an IM dose of atipamezole has not seemed toreverse the effects of medetomidine, an additional dose of atipamezole at 1/2 the volumeof the medetomidine dose may be given. (McGrath and Ko 1997b)
For treatment of amitraz toxicity:
a) 50 mcg/kg IM (Hugnet, Buronrosse et al. 1996)
Monitoring Parameters - Level of sedation and analgesia; heart rate; body temperature
Client Information - Atipamezole should be administered by veterinary professionals only.
Clients should be informed that occasionally vomiting, diarrhea, hypersalivation, excitation andtremors may be seen after atipamezole administration. Should these be severe or persist afterleaving the clinic, clients should contact the veterinarian.
Dosage Forms/Preparations/FDA Approval Status - Veterinary-Approved Products:
Atipamezole HCl for Injection 5 mg/ml in 10 ml multidose vials; Antisedan®; (Pfizer); (Rx)
Approved for use in dogs.
Human-Approved Products: None