Doses - DANAZOL

Dogs:

For adjunctive treatment of immune-mediated hemolytic anemia or thrombocytopenia:
a) 5 mg/kg PO q12h; usually used for the first two weeks of therapy in combination withcorticosteroids. (Thompson 1994)
b) 10 - 20 mg/kg/day (divided bid - tid) (Dougherty 1994)
c) Initially, (in addition to prednis(ol)one) danazol may be given at 10 mg/kg/day PO.
Once anemia improves, corticosteroids may be slowly tapered and eventually DC'd.
When remission maintained by danazol alone, may lower to 5 mg/kg/day. Slowly taperafter 2-3 months of normal hemograms with frequent monitoring of hemograms.(Bucheler and Cotter 1995)

Cats:

For adjunctive treatment of immune-mediated hemolytic anemia:
a) 5 mg/kg PO twice daily (Loar 1994)
Monitoring Parameters - For autoimmune hematologic disorders: 1) Efficacy (CBC, platelets, etc.); 2) Hepatic function, baseline and at regular intervals while on therapy.
Client Information - Clients should be informed that it may take several (2-3) months to see apositive response with this drug. They should monitor for hepatotoxicity (jaundice) or changes inhematologic status (bleeding, tarry stools, etc.).
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Danazol Oral Capsules 50 mg, 100 mg, 200 mg; Danocrine® (Sanofi-Winthrop), generic; (Rx)