Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

DICHLORPHENAMIDE

Chemistry - A carbonic anhydrase inhibitor, dichlorphenamide occurs as a white or nearly white, crystalline powder with a melting range of 235-240°C, and pKas of 7.4 and 8.6. It is very slightlysoluble in water and soluble in alcohol.

Storage, Stability, Compatibility

Store tablets in well-closed containers and at room temperature. An expiration date of 5 years after the date of manufacture is assigned to the commercially available tablets.

Pharmacology - DICHLORPHENAMIDE

See the discussion listed in the acetazolamide monograph immediately prior tothis one.
Uses, Indications - Dichlorphenamide is used for the medical treatment of glaucoma.

Pharmacokinetics - DICHLORPHENAMIDE

The pharmacokinetics of this agent have apparently not been studied in domestic animals. One report (Roberts 1985) states that after a dose of 2.2 mg/kg, the onset of action is 30 minutes, maximal effect in 2-4 hours, and duration of action is 6-12 hours in small animals.
Contraindications/Precautions, Adverse Effects, Warnings, Overdosage, & Drug
Interactions - See the discussion in the acetazolamide monograph found immediately prior to thisone.
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