EPRINOMECTIN
Chemistry/Storage/Stability- A member of the avermectin-class of antiparasitic agents, eprinomectin is also known as MK-397 or 4-epi-acetylamino-4-deoxy-avermectin B1. The commercially available product should be stored protected from light and kept at 86°F (30°C) or less.
Storage at up to 104°F (40°C) is permitted for a short period of time.
Oesophagostomum radiatum, Bunostomun phlebotomum and Trichuris spp. (adults only); cattle grubs; lice; mange mites; horn flies (for 7 days after treatment) and lungworms (Dictyocaulus vivaparus¯for 21 days after treatment).
Overdosage - Calves given up to 5X dosage showed no signs of adverse effects. One subject (of 6)showed signs of mydriasis when give a 10X dose.
Storage at up to 104°F (40°C) is permitted for a short period of time.
Pharmacology - EPRINOMECTIN
Eprinomectin binds selectively to glutamate-gated chloride ion channels whichoccur in invertebrate nerve and muscle cells. This leads to an increase in cell membrane permeabilityto chloride ions leading to paralysis and death of the parasite. Like ivermectin, eprinomectin alsoenhances the release of gamma amino butyric acid (GABA) at presynaptic neurons. GABA acts asan inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron innematodes or the muscle fiber in arthropods. These compounds are generally not toxic to mammalsas they do not have glutamate-gated chloride channels and these compounds do not readily crossthe blood-brain barrier.Uses, Indications
In cattle, eprinomectin is indicated for a variety gastrointestinal roundworms including adult and L4 stages of Haemonchus placei, Ostertagia ostertagi, Trichostrongylus axeiand colubriformis, Cooperia oncophora/punctata/surnabada, Nematodirus helvetianus,Oesophagostomum radiatum, Bunostomun phlebotomum and Trichuris spp. (adults only); cattle grubs; lice; mange mites; horn flies (for 7 days after treatment) and lungworms (Dictyocaulus vivaparus¯for 21 days after treatment).
Pharmacokinetics - EPRINOMECTIN
No information located.Contraindications, Precautions, Reproductive Safety
Do not give orally or intravenously. Upto 3X dosage demonstrated no adverse effect on breeding performance of cows or bulls.Adverse Effects, Warnings
At the time of writing, no adverse reactions have been reported.Overdosage - Calves given up to 5X dosage showed no signs of adverse effects. One subject (of 6)showed signs of mydriasis when give a 10X dose.