Doses - ISOTRETINOIN
Dogs: 
For sebaceous adenitis when more conservative treatments have failed: a) 1 mg/kg PO q12h for one month; if improvement is noted reduce dose to 1 mg/kg POonce daily> long term goal is to treat with either 1 mg/kg PO every other day or 0.5mg/kg once daily. (Rosser 1992)
For treatment of Schnauzer comedo syndrome: 1 mg/kg once daily or divided q12h PO.
For sebaceous adenitis in poodles; granulomatous sebaceous adenitis in viszlas: 1 - 2 mg/kgonce daily or divided q12h PO.
For epitheliotrophic lymphoma, cutaneous lymphoma: 2 mg/kg once daily or divided q12h
PO. (Power and Ihrke 1995)
Cats:For feline acne:
a) 5 mg/kg PO once daily (Hall and Campbell 1994)
b) 10 mg per cat once daily PO (Power and Ihrke 1995)
For epitheliotrophic lymphoma, cutaneous lymphoma: 10 mg/cat once daily PO. (Power and Ihrke 1995)
Monitoring Parameters - See Lab Considerations and Adverse Effects. 1) Efficacy 2) Liver function tests (baseline and if symptoms appear) 3)
Dogs:
Schirmer Tear tests (monthly¯especially in older dogs) 4) Cats: Weight. Client Information - Isotretinoin should be handled by pregnant females in the household with extreme care, if at all. Veterinarians must take the personal responsibility to educate clients of the potential risk of ingestion by pregnant females.
Milk or high fat foods will increase the absorption of etretinate. To reduce variability of absorption, either have clients consistently give with meals or not. Long term therapy can be quite expensive.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None