SODIUM IODIDE
Chemistry - Sodium iodide occurs as colorless, odorless crystals or white crystalline powder. Itwill develop a brown tint upon degradation. Approximately 1 gram is soluble in 0.6 ml of water and2 ml of alcohol.
Iodides should be given slowly intravenously and with caution to horses as severe generalizedreactions have been reported.
Anecdotal reports that iodides can cause abortion in cat le persist and label information of someveterinary products state not to use in pregnant animals. Clearly, potential risks versus benefits oftherapy must be weighed.
Overdosage - Excessive iodine in animals can cause excessive tearing, nasal discharge, scalyhaircoats/dandruff, hyperthermia, decreased milk production and weight gain, coughing, inappetenceand diarrhea.
Storage, Stability, Compatibility
Commercially available veterinary injectable products should generally be stored at room temperature (15- 30° C). Sodium iodide injection is reportedly incompatible with vitamins B & C injection.Pharmacology - SODIUM IODIDE
While the exact mode of action for its efficacy in treating actinobacillosis isunknown, iodides probably have some effect on the granulomatous inflammatory process. Iodideshave little, if any in vitro antibiotic activity.Uses, Indications
The primary use for sodium iodide is in the treatment of actinobacillosis andactinomycosis in cattle. It has been used as an expectorant with little success in a variety of speciesand occasionally as a supplement for iodine deficiency disorders. In horses, oral sodium iodide hasbeen the classical treatment for sporotrichosis.Pharmacokinetics - SODIUM IODIDE
Little published information appears to be available. Therapeutic efficacy ofintravenous sodium iodide for actinobacillosis is rapid, with beneficial effects usually seen within48 hours of therapy.Contraindications, Precautions, Reproductive Safety
Sodium iodide injection labels state thatit should not be given to lactating animals or to animals with hyperthyroidism. Do not inject intramuscularly (IM).Iodides should be given slowly intravenously and with caution to horses as severe generalizedreactions have been reported.
Anecdotal reports that iodides can cause abortion in cat le persist and label information of someveterinary products state not to use in pregnant animals. Clearly, potential risks versus benefits oftherapy must be weighed.
Adverse Effects, Warnings
In ruminants, the adverse effect profile is related to excessive iodine(see Overdosage below). Young animals may be more susceptible to iodism than adults. Foals havedeveloped goiter when mares have been excessively supplemented.Overdosage - Excessive iodine in animals can cause excessive tearing, nasal discharge, scalyhaircoats/dandruff, hyperthermia, decreased milk production and weight gain, coughing, inappetenceand diarrhea.