Doses - TRIPELENNAMINE HCL

It is recommended to warm the solution to near body temperature before injecting; give IMinjections into large muscle areas.

Dogs:

a) 1.1 mg/kg IM q6-12h prn (Package Insert; Re-Covr® - Solvay)
b) 1 mg/kg PO q12h; 1 mg/kg IM (Kirk 1986)

Cats:

a) 1.1 mg/kg IM q6-12h prn (Package Insert; Re-Covr® - Solvay)
b) 1 mg/kg PO q12h; 1 mg/kg IM (Kirk 1986)

Cattle:

a) 1.1 mg/kg (2.5 ml per 100 lbs body weight) IV (for more immediate effect) or IM q6-12h prn (Package Insert; Re-Covr® - Solvay)
b) As adjunctive treatment in "Downer Cow Syndrome" as a CNS stimulant: 0.5 mg/kg slow IV in conjunction with parenteral mineral treatment (Caple 1986)
c) 1 mg/kg IV or IM (Howard 1986)

Horses:

a) 1.1 mg/kg (2.5 ml per 100 lbs body weight) IM q6-12h prn (Package Insert; Re-Covr® - Solvay)
b) 1 mg/kg IM (Robinson 1987)

Swine:

a) 1 mg/kg IV or IM (Howard 1986)
Monitoring Parameters -
1) Clinical efficacy and adverse effects
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Tripelennamine HCl for Injection (Veterinary) 20 mg/ml in 20 ml, 100 ml, and 250 ml vials;
Generic (Phoenix) (Rx) Tripelennamine HCl injection is approved for use in cattle, horses, dogs, and cats. Treated cattle must not be slaughtered for food purposes for four days following the last treatment. Milk must not be used for food for 24 hours (2 milkings) aftertreatment. No specific tolerance for residues have been published

Human-Approved Products:

Tripelennamine HCl Oral Tablets 25 mg, 50 mg; PBZ® (Geigy);Pelamine® (Major); Generic;(Rx)
Tripelennamine HCl Extended-release tablets 100 mg; PBZ-SR® (Geigy); (Rx)Tripelennamine HCl Elixir: 37.5 mg (equivalent to 25 mg HCl) per 5 ml in 473 mls; PBZ®(Geigy) (Rx)
TSH - See Thyrotropin