Doses - ATROPINE SULFATE
Dogs: 
As a preanesthetic adjuvant: a) 0.022 - 0.044 mg/kg IM or SQ (Muir )
b) 0.074 mg/kg IV, IM or SQ (Package Insert; Atropine Injectable, S.A. - Fort Dodge)
c) 0.02 - 0.04 mg/kg SQ, IM or IV (Morgan 1988)
For adjunctive treatment of bradycardias, Incomplete AV block, etc:
a) 0.022 - 0.044 mg/kg IM, SQ, or IV prn; or 0.04 mg/kg PO tid-qid (Morgan 1988)
b) 0.02 - 0.04 mg/kg IV or IM (Russell and Rush 1995)
For treatment of cholinergic toxicity:
a) 0.2 - 2.0 mg/kg ; give 1/4th of the dose IV and the remainder SQ or IM (Morgan 1988)
For treatment of bronchoconstriction:
a) 0.02 - 0.04 mg/kg for a duration of effect of 1 - 1.5 hours (Papich 1986)
Cats: 
As a preanesthetic adjuvant: a) 0.022 - 0.044 mg/kg IM or SQ (Muir ))
b) 0.074 mg/kg IV, IM or SQ (Package Insert; Atropine Injectable, S.A. - Fort Dodge)
c) 0.02 - 0.04 mg/kg SQ, IM or IV (Morgan 1988)
For treatment of bradycardias:
a) 0.022 - 0.044 mg/kg IM, SQ, or IV prn; or 0.04 mg/kg PO tid-qid (Morgan 1988)
b) 0.02 - 0.04 mg/kg SQ, IM or IV q4-6h (Miller 1985)
For treatment of cholinergic toxicity:
a) 0.2 - 2.0 mg/kg ; give 1/4th of the dose IV and the remainder SQ or IM (Morgan 1988)
Cattle: 
As a preanesthetic: a) Because of a lack of extended efficacy and potential adverse reactions, atropine is not used routinely as a preoperative agent in ruminants. If it is desired for use, a dose of 0.06 - 0.12 mg/kg IM has been suggested. (Thurmon and Benson 1986)
For adjunctive treatment of bovine hypersensitivity disease:
a) 1 gram per cow once daily followed by 0.5 gram/cow in 2 - 3 days (method of administration not specified) (Manning and Scheidt 1986)
For treatment of cholinergic toxicity (organophosphates):
a) 0.5 mg/kg (average dose); give 1/4th of the dose IV and the remainder SQ or IM; may repeat q3-4h for 1-2 days (Bailey 1986)
Horses: 
For treatment of bradyarrhythmias due to increased parasympathetic tone: a) 0.02 mg/kg IV (Muir and McGuirk 1987a)
b) 0.045 mg/kg parenterally (Hilwig 1987)
As a bronchodilator:
a) 5 mg IV for a 400-500 kg animal (Beech 1987)
For organophosphate poisoning:
a) Approximately 1 mg/kg given to effect IV (use mydriasis and absence of salivation as therapy endpoints), may repeat every 1.5 - 2 hours as required subcutaneously (Oehme 1987)
b) 0.22 mg/kg, 1/4th of the dose administered IV and the remainder SQ or IM (Package
Insert; Atropine Injectable, L.A. - Fort Dodge)
Swine:The equine dose (above) may be used to initially treat organophosphate toxicity in swine.
As an adjunctive preanesthetic agent:
a) 0.04 mg/kg IM (Thurmon and Benson 1986)
Sheep & Goats:
As a preanesthetic: a) Because of a lack of extended efficacy and potential adverse reactions, atropine is not used routinely as a preoperative agent in ruminants. If it is desired for use, a dose of 0.15 - 0.3 mg/kg IM has been suggested. (Thurmon and Benson 1986)
For treating organophosphate toxicity: Use the dose for cattle (above).
Birds: 
For organophosphate poisoning: a) 0.1 - 0.2 mg/kg IM or SQ prn (Clubb 1986)
As a preanesthetic:
a) 0.04 - 0.1 mg/kg IM or SQ once (Clubb 1986)
Reptiles: 
a) For organophosphate toxicity in most species: 0.1 - 0.2 mg/kg subQ or IM as needed. For ptyalism in tortoises: 0.05 mg/kg (50 mg/kg) Sub Q or IM once daily. (Gauvin1993)
Monitoring Parameters - Dependent on dose and indication
Client Information - Parenteral atropine administration is best performed by professional staffand where adequate cardiac monitoring is available. If animal is receiving atropine tablets, allowanimal free access to water and encourage drinking if dry mouth is a problem.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: Atropine is approved for use in dogs, cats, horses, cattle, sheep, and swine. No information is available regarding meat or milk withdrawal. Atropine products areavailable by prescription only.
Atropine Sulfate for Injection
0.5 mg/ml 30 ml, 100 ml vials
2 mg/ml 100 ml vial
15 mg/ml (Organophosphate Tx) 100 ml vial
Human-Approved Products:
Atropine Sulfate for Injection0.05 mg/ml in 5 ml syringes
0.1 mg/ml in 5 and 10 ml syringes
0.3 mg/ml in 1 ml and 30 ml vials
0.4 mg/ml in 1 ml amps and 1, 20, and 30 ml vials
0.5mg/ml in 1 & 30 ml vials and 5 ml syringes
0.8 mg/ml in 0.5 & 1 ml amps and 0.5 ml syringes
1 mg/ml in 1 ml amps & vials and 10 ml syringes
Atropine Sulfate Tablets 0.4 mg in 100's
Also see the monograph for atropine sulfate for ophthalmic use in the appendix.