Doses - ISOPROTERENOL HCL

Note: Because of the cardiostimulatory properties of isoproterenol, its parenteral use in human medicine for the treatment of bronchospasm has been largely supplanted by other more beta2 specific drugs (e.g., terbutaline) and administration methods (nebulization). Use with care.

Dogs:

For sinoatrial arrest, sinus bradycardia, complete AV block:
a) 0.4 mg in 250 ml D5W drip slowly to effect; or Isuprel® Glossets 5 - 10 mg sublingually or rectally q 4-6h (Tilley and Miller 1986)
b) 0.04 - 0.08 micrograms/kg/min IV infusion; or 0.1 - 0.2 mg IM, SQ q4h; or 0.4 mg in 250 ml D5W IV slowly (Morgan 1988)
For bronchodilitation:
a) 0.1 - 0.2 mg q6h IM or SQ (Papich 1986)

Cats:

For sinoatrial arrest, sinus bradycardia, complete AV block:
a) 0.4 mg in 250 ml D5W drip slowly to effect (Tilley and Miller 1986))
For feline asthma:
a) 0.2 mg in 100 ml of D5W and give IV to effect tid; or 0.004 - 0.006 mg IM q30 minutes prn (Morgan 1988)

Horses:

For short-term bronchodilitation:
a) Dilute 0.2 mg in 50 ml of saline and administer 0.4 micrograms/kg as an IV infusion, monitor heart rate continuously and discontinue when heart rate doubles. Effects may only last for an hour. (Derksen 1987)
Monitoring Parameters -

1) Cardiac rate/rhythm

2) Respiratory rate/auscultation during anaphylaxis

3) Urine flow if possible

4) Blood pressure, and blood gases if indicated and if possible
Client Information - Isoproterenol for injection should be used only by trained personnel in asetting where adequate monitoring can be performed. Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Isoproterenol for Injection 1:5000 solution (0.2 mg/ml) in 1 & 5 ml amps; Isuprel® (Winthrop
Pharm.); Generic; (Rx)
Isoproterenol sublingual or rectal Glossets 10 mg, 15 mg; Isuprel® Glossets (Winthrop); (Rx)
Isoproterenol is also available in aerosol or solution form for oral inhalation.