Doses - IVERMECTIN
Dogs: 
As a preventative for heartworm: a) 0.006 mg/kg PO once monthly (Hribernik 1989)
b) 0.003 - 0.006 mg/kg PO once monthly (Knight 1988)
c) Minimum dosage of 5.98 micrograms/kg (0.00598 mg/kg) PO per month (Rawlingsand Calvert 1989)
d) Minimum dosage of 6 micrograms/kg (0.006 mg/kg) PO per month. Three tablet sizesare available: For dogs up to 25 lbs (68 micrograms); 26-50 lbs (136 micrograms); and51-100 lbs (272 micrograms). Dogs weighing more than 100 lbs. should receiveadditional drug so that the minimum dosage is covered. (Package insert; Heartgard30®¯MSD)
As a microfilaricide:
a) 3-4 weeks after aldulticide therapy, admit to hospital and administer 0.05 mg/kg (Dilute10 mg/ml solution (Ivomec®) to a 1:10 solution with propylene glycol). Monitor forsymptoms of toxicity (depression, mydriasis, ataxia, vomiting, diarrhea, and shock)throughout the day. If adverse effects are severe (usually less than 5% of the time), treatwith fluids and corticosteroids. If no adverse effects are noted, animal may be sent hometo return in 3 weeks for microfilaricide concentration test. If negative at that time, beginprophylaxis therapy. If positive, recheck in one week. If 4 weeks after therapymicrofilaria persist, reevaluate for adult heartworms. See the complete reference formore information. (Hribernik 1989)
b) 50 - 200 micrograms/kg (0.05 - 0.2 mg/kg) as a single dose; contraindicated in collies.(Knight 1988)
c) 4 weeks after aldulticide therapy, give 50 micrograms/kg PO (dilute as in "a" above) inthe morning. Monitor for adverse effects throughout the day; if no serious effects, maydischarge in late afternoon. Do not use in Collies or Collie-Mix breeds. (Rawlings and Calvert 1989)
As an ectoparasiticide (miticide):
a) For treatment of Sarcoptes scabiei or Otodectes cynotis infestations: 300 micrograms/kg (0.3 mg/kg) SQ or PO; repeat in 14 days. (Paradis 1989)
As an endoparasiticide:
a) For treatment of parasitic lung disease (Capillaria spp.): 0.2 mg/kg PO once. (Bauer1988)
b) For roundworms, hooks, or whips: 200 micrograms/kg PO once. DO not use in Collies. (Upson 1988)
c) For Oslerus osleri: 0.4 mg/kg SubQ once (Reinemeyer 1995)
d) For Eucoleus boehmi: 0.2 mg/kg PO once (Reinemeyer 1995)
e) For Pneumonyssoides caninum: 0.2 mg/kg SubQ once (Reinemeyer 1995)
Cats: 
As a preventative for heartworm: a) Minimum effective dosage: 0.024 mg/kg (24 micrograms/kg) PO every 30-45 days. (Note: also controls hookworms at this dosage.) (Knight 1995)
For Aelurostrongylus abstrusus:
a) 0.4 mg/kg SubQ once (Reinemeyer 1995)
Cattle: 
For susceptible parasites: a) 200 micrograms/kg SQ. Doses greater than 10 ml should be given at two separate sites. (Paul 1986)
b) For psoroptic mange: 200 mg/kg IM (Note: Reference was written before approval of the SQ labeled bovine product); isolate from other cattle for at least 5 days after treatment. (Mullowney 1986)
c) 200 micrograms/kg (0.2 mg/kg) SQ under the loose skin in front of or behind the shoulder. (Product Information; Ivomec® Inj. for Cattle 1%¯MSD)
Horses: 
For susceptible parasites: a) 200 micrograms/kg (0.2 mg/kg) PO using oral paste or oral liquid. (Product
Information; Eqvalan®¯MSD)
b) 0.2 mg/kg PO; 0.2 mg/kg PO at 4 day intervals for lice and mange. (Robinson 1987)
c) As a larvacidal for arterial stages of S. vulgaris: 0.2 mg/kg once. (Herd 1987)
Swine: 
For susceptible parasites: a) 300 micrograms/kg (0.3 mg/kg) SQ in the neck immediately behind the ear. (Product
Information; Ivomec® Inj. for Swine 1%¯MSD)
b) For general control of endo- and ectoparasites in potbellied pigs: 300 micrograms/kg
SubQ or IM once for internal parasites and repeated in 10-14 days for external parasites(only partially effective against whipworms¯see fenbendazole) (Braun 1995)
Sheep: 
For susceptible parasites: a) 200 micrograms/kg for nasal bot infection. (Bennett 1986)
b) 200 micrograms/kg SQ for one dose (goats also). (Upson 1988)
Llamas:
For susceptible parasites:
a) 0.2 mg/kg PO or SQ for one dose (Cheney and Allen 1989), (Fowler 1989)
Birds: 
For susceptible parasites: a) For ascarids, Capillaria and other intestinal worms, Knemidocoptes pilae (scaly face and leg mites): Dilute to a 2 mg/ml concentration. After diluting product, use immediately.
Most birds: Inject 220 micrograms/kg IM.
Parakeets: 0.02 mg/30 g (2000 micrograms/30 gram) IM.
Amazon: 0.1 mg IM
Macaw: 0.2 mg IM
Finches: 0.02 mg (Stunkard 1984)
b) For ascarids, coccidia and other intestinal nematodes, Oxysipura, gapeworms,
Knemidocoptes pilae (scaly face and leg mites): Dilute bovine preparation (10 mg/ml)1:4 with propylene glycol.
For most species: 200 micrograms/kg IM or orally; repeat in 10-14 days.
Budgerigars: 0.01 ml of diluted product (see above) IM or PO (Clubb 1986)
c) 200 micrograms/kg (0.2 mg/kg) SQ; dilute using propylene glycol. (Sikarskie 1986)
Reptiles: 
For most nematodes, ectoparasites: a) For lizards, snakes, and alligators: 0.2 mg/kg (200 mg/kg) IM, SubQ, or PO once; repeatin 2 weeks. Note: Ivermectin is toxic to chelonians. (Gauvin 1993)
Monitoring Parameters -
Client Information - When using large animal products the manufacturer recommends not eating or smoking and to wash hands after use. Avoid contact with eyes. Dispose of unused products and containers by incineration or in approved-landfills. Ivermectin may adversely affect fish or other water-borne organisms if disposed in water.
Contact veterinarian if any treated animal exhibits symptoms of toxicity (see Adverse effects and Overdosage sections above).
Dosage Forms/Preparations/FDA Approval Status/Withholding Times -
Veterinary Approved Products -
Ivermectin for Injection 10 mg/ml (1%) in 50 ml, 200 ml, 500 ml and 1000 ml bottles
Ivomec® 1% Injection for Cattle (MSD-AgVet); (OTC) Approved for use in nonlactating dairycattle, beef cattle and reindeer. Slaughter withdrawal = 35 days (cattle); 56 days (reindeer andbison)
Ivermectin for Injection 10 mg/ml (1%) & Clorsulon 100 mg/ml; Ivomec® Plus Injection(MSD-AgVet); (OTC) Approved for use in cattle.
Ivermectin Oral Paste 0.153% (1.53 mg/gram) in 10.4 oz tubes; Ivomec® Cat le Paste 0.153%(MSD-AgVet); (OTC) Approved for use in nonlactating dairy cattle, and beef cattle. Slaughterwithdrawal = 24 days
Ivermectin for Injection 10 mg/ml (1%) in 50 ml, 200 ml, 500 ml bottles; Ivomec® 1% Injectionfor Swine (MSD-AgVet); (OTC) Approved for use in swine. Slaughter withdrawal = 18 days
Ivermectin for Injection 2.7 mg/ml (0.27%) in 200 ml bottles; Ivomec® 0.27% Injection for
Feeder and Grower Pigs (MSD-AgVet); (OTC) Approved for use in swine. Slaughterwithdrawal = 18 days
Ivermectin Oral Paste 1.87% (18.7 mg/gram) in 6.08 g syringes; Eqvalan® Paste 1.87% (MSD-AgVet), Zimectrin® Paste (Farnam); (OTC) Approved for use in horses (not intended forfood purposes).
Ivermectin Liquid 1% (10 mg/ml) in 50 ml and 100 ml btls (for tube administration; not forinjection);Eqvalan® Liquid for Horses (MSD-AgVet); (Rx) Approved for use in horses (notintended for food purposes).
Ivermectin Oral Tablets 68 micrograms, 136 micrograms, 272 micrograms (Plain or Chewable)in 6 or 9 packs; Heartgard 30® (MSD-AgVet) (Rx) Approved for use in dogs.
Ivermectin/Pyrantel Oral Tablets 68 mcg/57 mg, 136 mcg/114mg, 272 mcg/228 mg) in packs;
Heartgard 30® Chewables Plus(MSD-AgVet) (Rx) Approved for use in dogs.