Doses - ACETYLCYSTEINE
Dogs: 
For acetominophen toxicity: a) 150 mg/kg PO or IV initially, then 50 mg/kg q4h for 17 additional doses. (Bailey 1986a)
b) Loading dose of 140 mg/kg PO or IV (as a 5% solution), then 70 mg/kg every 4 hoursfor 3-5 treatments. (Oehme 1986a)
c) Loading dose of 140 mg/kg PO, then 70 mg/kg PO every 6 hours for 7 treatments.(Grauer and Hjelle 1988a)
For respiratory use:
a) 50 ml/hr for 30-60 minutes every 12 hours by nebulization. (Kirk 1986)
Cats: 
For acetominophen toxicity: a) 140 mg/kg PO or IV (as a 5% solution) initially, then 70 mg/kg q4h PO or IV for 3-5 additional treatments. (Reid and Oehme 1989), (Oehme 1986a)
b) 150 mg/kg PO or IV initially, then 50 mg/kg q4h for 17 additional doses. (Bailey 1986a)
c) For methemoglobinemia secondary to acetominophen or other toxins: Using a 10% solution give 1.4 ml/kg (0.7 ml/kg if using 20% solution) PO q8h for a total of 3-7 treatments. (Maggio-Price 1988)
d) Loading dose of 140 mg/kg PO, then 70 mg/kg PO every 6 hours for 7 treatments. (Grauer and Hjelle 1988a)
e) 140 mg/kg PO initially (as a 5% solution in water (isotonic) or in 5-10% dextrose), then 70 mg/kg PO for 3-5 treatments. (Mount 1989)
For respiratory use:
a) 50 ml/hr for 30-60 minutes every 12 hours by nebulization. (Kirk 1986)Monitoring Parameters - When used for acetominophen poisoning:
Client Information - This agent should be used in a clinically supervised setting only.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None
Human-Approved Products:
Acetylcysteine (as sodium) 10% (100 mg/ml) and 20% (200 mg/ml) in 4 ml, 10 ml and 30 mlvials for oral inhalation, oral solution, or intratracheal instillation.; Mucomyst® (Apothecon);Mucosil-10 ®(Dey Labs); Mucosil-20 ®(Dey Labs); Generic. (Rx)
Acetylsalicylic Acid ¯ See AspirinACTH ¯ See CorticotropinActivated Charcoal ¯ See Charcoal, Activated