FENPROSTALENE

Chemistry - Fenprostalene is a methyl ester synthetic analogue of prostaglandin F2alpha. Noother information was located on the chemistry of the compound.

Storage, Stability, Compatibility

Fenprostalene injection should be stored at room temperature.
At temperatures below 5°C, the commercial product may congeal, but stability and potency areunaffected. Viscosity should normalize after rewarming the vial.

Pharmacology - FENPROSTALENE

Fenprostalene exhibits pharmacologic actions similar to those of otherprostaglandins of the F series. Effects on the female reproductive system include stimulation ofmyometrial activity, relaxation of the cervix, inhibition of steroidogenesis by corpora lutea, andpotentially lysing corpora lutea.
Uses, Indications - Fenprostalene is labeled for use as an abortifacient in feedlot heifers during thefirst 150 days of gestation and for estrus synchronization in beef and non-lactating dairy cattle.

Pharmacokinetics - FENPROSTALENE

The pharmacokinetics of fenprostalene have been studied in lactating dairy cattle (Tomlinson, Spires, and Bowen 1985). The drug is apparently more slowly absorbed and eliminated than other prostaglandins. The percentage of drug excreted in the milk was not appreciably greater than other prostaglandins and is practically gone 48 hours after injection.
Contraindications/Precautions - Unless being used as an abortifacient or parturition inducer, fenprostalene should not be used during pregnancy in all species. Fenprostalene is contraindicated in animals with bronchoconstrictive respiratory disease (e.g., asthma, "heavey" horses).
Give fenprostalene via the subcutaneous route only; do not administer intravenously nor intramuscularly. When injecting use a 16 gauge 1/2 - 3/4 inch needle. Suggested areas of injection are the neck, area behind shoulder or escutcheon (areas with freer movement between skin and underlying tissues).

Adverse Effects, Warnings

The adverse reaction reported with fenprostalene is a local reaction with possible bacterial infection at the injection site. Rarely, the infection may disseminate systemically and result in mortality.
Overdosage - No information was located. Should an inadvertent overdose occur, it is suggested tomonitor the animal carefully and treat supportively if necessary.

Drug Interactions

Other oxytocic agents' activity may be enhanced by fenprostalene. Reduced effect of fenprostalene would be expected with concomitant administration of a progestin.