Doses - MIBOLERONE

Dogs:

For suppression of estrus (treatment must begin at least 30 days prior to proestrus):
a) Bitches weighing:0.5-11 kg: 30 micrograms (0.3 ml) PO per day12-22 kg: 60 micrograms (0.6 ml) PO per day23-45 kg: 120 micrograms (1.2 ml) PO per day>45 kg:180 micrograms (1.8 ml) PO per day
German shepherds or German shepherd crosses: 180 micrograms (1.8 ml) PO per day;regardless of weight (Package Insert; Cheque® Drops ¯Upjohn)
b) As above, but should dog come into estrus after receiving the drug for 30 or more days.
Stop drug and determine that the dog is not pregnant before resuming therapy. If ownercompliance has been determined, increase dosage by 20-50%. (Woody 1988), (Burke1985)
For pseudocyesis (false pregnancy):
a) Use 10 times the dosage listed above for suppression of estrus PO once daily for 5days (Barton and Wolf 1988)
b) 16 micrograms/kg PO once daily for 5 days (Concannon 1986)
For treatment of severe galactorrhea:
a) 8 - 18 micrograms/kg PO once a day for 5 days. Once discontinued, prolactin maysurge and galactorrhea resume. (Olson and Olson 1986)
Cats: WARNING: Because of the very low margin of safety with this drug in cats, it cannot berecommended for use in this species.
Monitoring Parameters -

1) Symptoms of estrus

2) Liver function tests (baseline, annual, or prn)

3) Physical examination of genitalia
Client Information - It must be stressed to owners that compliance with dosage and administration directions are crucial for this agent to be effective.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Mibolerone Oral Drops 100 micrograms/ml in 55 ml dropper bottles; Cheque® Drops(Upjohn); (Rx) Approved for use in dogs only.
Human-Approved Products: None