PREDNISOLONE, PREDNISOLONE SODIUM SUCCINATE, PREDNISOLONE ACETATE, PREDNISONE
Note: Although separate entities, prednisone is rapidly converted by the liver in vivo to prednisolone. Except for patients in frank hepatic failure, the drugs can, for all intents, be consideredequivalent.
Chemistry - Prednisolone and prednisone are synthetic glucocorticoids. Prednisolone and prednisolone acetate occur as odorless, white to practically white, crystalline powders. Prednisolone isvery slightly soluble in water and slightly soluble in alcohol. The acetate ester is practically insoluble in water and slightly soluble in alcohol. The sodium succinate ester is highly water soluble.
Prednisolone is also known as deltahydrocortisone or metacortandralone.
Prednisone occurs as an odorless, white to practically white, crystalline powder. Prednisone is veryslightly soluble in water and slightly soluble in alcohol. Prednisone is also known as deltacortisoneor deltadehydrocortisone.
Storage, Stability, CompatibilityPrednisolone and prednisone tablets should be stored in well-closed containers. All prednisone and prednisolone products should be stored at temperatures lessthan 40°, and preferably between 15-30°C; avoid freezing liquid products. Do not autoclave. Oralliquid preparations of prednisone should be stored in tight containers.
Prednisolone sodium succinate should be stored at room temperature and protected from light(store in carton). After reconstitution, the product is recommended to be used immediately and notstored.
Little data appears to be available regarding the compatibility of prednisolone sodium succinateinjection (Solu-Delta Cortef® ¯ Upjohn) with other products. A related compound, prednisolonesodium phosphate is reportedly compatible with the following drugs/solutions: ascorbic acidinjection, cephalothin sodium, cytarabine, erythromycin lactobionate, fluorouracil, heparin sodium, methicillin sodium, penicillin G potassium/sodium, tetracycline HCl and vitamin B-Complex with
C. It is reportedly incompatible with: calcium gluconate/gluceptate, dimenhydrinate, metaraminolbitartrate, methotrexate sodium, prochlorperazine edisylate, polymyxin B sulfate, promazine HCl, and promethazine HCl. Compatibility is dependent upon factors such as pH, concentration, temperature and diluents used. It is suggested to consult specialized references for more specificinformation (e.g., Handbook on Injectable Drugs by Trissel; see bibliography).