Doses - PROMAZINE HCL

Dogs:

a) 2.2 - 6.6 mg/kg IV as a preanesthetic (Barbiturate dose is then reduced by 1/3 - 1/2.(Lumb and Jones 1984)
b) 2.2 - 4.4 mg/kg IM as a sedative (Morgan 1988)
c) 2 - 4 mg/kg IM or IV (Davis 1985a)
d) 2 - 6 mg/kg IM or IV repeat q4-6h prn; as an antiemetic reduce dose by 1/3-1/2 (Booth1988a)

Cats:

a) 2.2 - 4.4 mg/kg IM as a sedative (Morgan 1988)
b) 2.2 - 4.4 mg/kg IM or IV (Kirk 1986)

Cattle:

a) 1.1 mg/kg IV as a tranquilizer (Lumb and Jones 1984)
b) 0.44 - 1.0 mg/kg IV or IM (Howard 1986)

Horses:

a) 1.1 mg/kg IV as a tranquilizer (Lumb and Jones 1984)
b) 0.4 - 1.0 mg/kg IV (Robinson 1987)
c) 0.99 - 1.98 mg/kg PO (equivalent to 1.63 - 3.26 grams/100 lbs of body weight) Onelevel capful of promazine granules (Fort Dodge) will treat 300 lbs of horse at a dosageof approximately 1.45 mg/kg. Onset of action generally starts in 45 minutes and lastsfor 4-6 hours. (Package Insert - Promazine Granules, Fort Dodge)

Swine:

a) 0.44 - 1.0 mg/kg IV or IM (Howard 1986)
b) Preanesthetic: 2 mg/kg with atropine (0.07 - 0.09 mg/kg) and meperidine (1 - 2mg/kg)(Booth 1988a)
Monitoring Parameters -

1) Cardiac rate/rhythm/blood pressure if indicated and possible to measure

2) Degree of tranquilization

3) Body temperature (especially if ambient temperature is very hot or cold)
Client Information - May discolor the urine to a pink or red-brown color; this is not abnormal.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Promazine HCl Granules (Veterinary); 10.25 oz containers containing 8 grams of promazine
HCl; each gram of granules contains 27.5 mg. of promazine HCl; (Fort Dodge); (Rx)
Approved for use in horses.

Human-Approved Products:

Promazine HCl for Injection 2 mg/ml in 10 ml vials; 5 mg/ml in 2 ml, 10 ml, &100 ml vials;
Sparine® (Wyeth-Ayerst), generic; (Rx)
Promazine HCl tablets 25 mg, 50 mg, 100 mg; Sparine® (Wyeth-Ayerst); Prozine-50® (Hauck);generic, (Rx)
Promazine HCl Oral Syrup 2 mg/ml in 120 ml bottles; Sparine® (Wyeth); (Rx)