Doses - PANCRELIPASE

Dogs:

For pancreatic exocrine insufficiency:
a) 1 - 1.5 teaspoonsful with each meal mixed with food. Mix with food thoroughly andallow to stand for 15-20 minutes before feeding. Dosage should be adjusted as necessary. Best results are usually obtained by feeding small meals frequently (at least 3times per day). (Package Insert; Viokase®-V Powder - Fort Dodge)
b) 1 - 2 teaspoons of powder of crushed tablets with meals; adjust dose according toclinical response. Not necessary to incubate with food before administering. If enzymesupplementation is inadequate, give cimetidine (5 - 10 mg/kg PO tid 30 minutes beforemeals) to reduce gastric acid destruction of enzymes (Bunch 1988)
c) Initially, 2 tsp of powdered extract per 20 kg of body weight mixed with food immediately prior to feeding; feed twice daily. Once clinical improvement has occurred, dosage may be varied to obtain efficacy with the minimum dose required. Most animalsrequire at least 1 tsp. Some dogs may be satisfactorily controlled with once dailyfeedings. (Williams 1989)

Cats:

For pancreatic exocrine insufficiency:
a) 0.5 - 0.75 teaspoonsful with each meal mixed with food. Mix with food thoroughly andallow to stand for 15-20 minutes before feeding. Dosage should be adjusted as necessary. Best results are usually obtained by feeding small meals frequently (at least 3times per day). (Package Insert; Viokase®-V Powder - Fort Dodge)

Birds:

For pancreatic exocrine insufficiency (used in birds that are polyphagic "going light", passingwhole seeds, and slow in emptying crops):
a) 1/8 tsp per kg. Mix with moistened feed or administer by gavage. Incubate with food for15 minutes prior to gavage. (Clubb 1986)
Monitoring Parameters -

1) Animal's weight

2) Stool consistency, frequency
Client Information - Powder spilled on hands should be washed off or skin irritation may develop. Avoid inhaling powder; causes mucous membrane irritation and may trigger asthma attacksin susceptible individuals.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times -Note: There are several dosage forms (both human and veterinary-label) available containing pancrelipase, includingoral capsules, oral delayed-release capsules, tablets, and delayed-released tablets. Most small animalpractitioners feel that the oral powder is most effective, however.
Veterinary-Approved Products:
Powder containing (approximately) per teaspoonful (2.8 grams): 57, 000 U lipase; 285, 000 Uprotease; 428, 000 U amylase; 8 oz bottle; Viokase®-V Powder (Fort Dodge); (Rx) Approvedfor use in dogs and cats.
Powder containing (approximately) per teaspoonful (2.8 grams): 61, 000 U lipase; 330, 000 Uprotease; 440, 000 U amylase; 8 oz bottle; Pancrezyme® Powder (Daniels); (Rx) Approvedfor use in dogs and cats.