Doses - PENICILLIN G

Dogs:

Cats:

For susceptible infections:
a) Penicillin G potassium: 20, 000 Units/kg IV, IM, SQ q4h or 40, 000 IU/kg PO on anempty stomach q6h
Penicillin G sodium: 20, 000 Units/kg IV, IM, SQ q4h
Penicillin G procaine: 20, 000 Units/kg IM, SQ q12-24h
Penicillin G benzathine: 50, 000 IU/kg IM q5 days (Upson 1988)
b) Penicillin G potassium/sodium: 20, 000 - 40, 000 Units/kg IV, IM, q6h
Penicillin G procaine: 22, 000 Units/kg IM, SQ q12h. Doses may be increased to 80, 000
IU/kg per day, Actinomyces infections may require 100, 000 - 200, 000 IU/kg IM daily.(Ford and Aronson 1985)
c) Penicillin G potassium/sodium: 20, 000 Units/kg IV, IM, q4h or 40, 000 IU/kg PO on anempty stomach q6h
Penicillin G procaine: 20, 000 Units/kg IM, SQ q12-24h.
Penicillin G benzathine: 40, 000 IU/kg q5 days IM (Kirk 1989)
d) Penicillin G sodium or potassium: 22, 000 - 55, 000 IU/kg IV or IM q6-8h (Aronson and Aucoin 1989)
Cattle (and other ruminants unless specified):
For susceptible infections:
a) Cattle: Penicillin G procaine: 44, 000 - 66, 000 Units/kg IM, SQ once daily
Penicillin G benzathine: 44, 000 - 66, 000 Units/kg IM, or SQ q2days (Upson 1988)
b) Cattle for bovine respiratory disease complex: Procaine penicillin G 66, 000 IU/kg IM or SQ once daily. Recommend 20 day slaughter withdrawal at this dosage. (Hjerpe 1986)
c) Procaine penicillin G: 40, 000 IU/kg IM once daily.
Procaine penicillin G/benzathine penicillin G combination: 40, 000 IU/kg IM once.(Howard 1986)
d) Procaine penicillin G: 10, 000 - 20, 000 IU/kg IM q12-24h.
Benzathine penicillin G: 10, 000 - 20, 000 IU/kg IM, SQ q48h. (Jenkins 1986)

Horses:

For susceptible infections:
a) Penicillin G potassium: 5000 - 50, 000 Units/kg IV qid
Penicillin G sodium: 5000 - 50, 000 Units/kg IV qid
Penicillin G procaine: 5000 - 50, 000 Units/kg IM bid (Robinson 1987)
b) Penicillin G sodium: 25, 000 - 50, 000 Units/kg IV, IM q6h
Penicillin G procaine: 20, 000 - 100, 000 Units/kg IM q12h
Penicillin G benzathine: 50, 000 Units/kg IM q2 days (Upson 1988)
c) Initially give Penicillin G (aqueous, sodium salt used in experiment) 10, 000 IU/kg IMwith procaine penicillin G at 15, 000 IU/kg IM q12h. If infection is severe, penicillin Gsodium at 10, 000 IU/kg at the same time as the procaine penicillin G. (Love et al. 1983)
d) For treatment of botulism: Penicillin G sodium or potassium 22, 000 - 44, 000 IU/kg IVqid (do not use oral penicillin therapy). (Johnston and Whitlock 1987)
e) For preoperative antibiotic prophylaxis for colic: Penicillin G potassium 40, 000 IU IVqid with gentamicin 2.2 mg/kg IV tid. (Stover 1987)
f) For respiratory infections (Streptococci): Initially, 20, 000 - 40, 000 U/kg of aqueouspenicillin G (sodium/potassium) IM with 20, 000 u/kg IM of procaine penicillin Gwhich is then continued bid. (Beech 1987a)
g) For foals: Penicillin G Na or K: 25, 000 - 50, 000 U/kg IV q6-8h;
Procaine penicillin G 25, 000 - 50, 000 U/kg IM q12h. Use the longer dose interval orsmaller dose in premature foals or those less than 7 days old. (Caprile and Short 1987)
h) Procaine penicillin G 25, 000 Units/kg IM q12-24h
Penicillin G sodium: 15, 000 - 20, 000 U/kg IV or IM q6h (Baggot and Prescott 1987)
i) Penicillin G potassium: 12, 500 - 100, 000 Units/kg IV q4h
Penicillin G sodium: 12, 500 - 100, 000 Units/kg IV q4h
Penicillin G procaine: 20, 000 - 50, 000 Units/kg IM q12h (Brumbaugh 1987)

Swine:

For susceptible infections:
a) Procaine penicillin G: 40, 000 IU/kg IM once daily.
Procaine penicillin G/benzathine penicillin G combination: 40, 000 IU/kg IM once. (Howard 1986)
b) Procaine penicillin G: 6, 600 IU/kg IM once daily for not more than 4 days.
Procaine penicillin G/benzathine penicillin G combination: 11, 000 - 22, 000 IU/kg IM once. (Wood 1986)

Birds:

For susceptible infections:
a) In turkeys: Procaine penicillin G/benzathine penicillin G combination: 100 mg/kg IM ofeach drug once a day or every 2 days. Use cautiously in small birds as it may causeprocaine toxicity. (Clubb 1986)
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Penicillin G Procaine Injection 300, 000 Units/ml in 100 ml and 250 ml bottles
Crystacillin® 300 A.S. Veterinary (Solvay); (OTC) Approved for use in cat le, sheep, horses, and swine. Do not exceed 7 days of treatment in non-lactating dairy cattle, beef cattle, swine or sheep, and 5 days in lactating dairy cattle. Milk withdrawal = 48 hours. Slaughterwithdrawal: Calves (non-ruminating) 7 days; cattle 4 days; sheep 8 days; swine 6 days.
Note: These withdrawal times are for the labeled dosage of 6, 600 U/kg once daily whichis rarely used clinically today. Actual withdrawal times may be longer. There are othergenerically labeled products available that may have different withdrawal times; refer tolabel for more information.
Note: There are several penicillin G procaine combination products available for the veterinarymarket. These products may contain dihydrostreptomycin, streptomycin or novobiocin, and beavailable in either intramammary or injectable dosage forms.
Penicillin G Benzathine 150, 000 U/ml with Penicillin G Procaine Injection 150, 000 Units/ml for
Injection in 100 ml and 250 ml vials
Flo-Cillin® (Fort Dodge), Pen BP-48® (Pfizer), Crystiben® (Solvay), Dual-Pen®(TechAmerica), generic; (OTC) Approved (most products) in dogs, horses and beefcattle. Slaughter withdrawal: cattle=30 days. Actual species approvals and withdrawaltimes may vary with the actual product; refer to the label of the product you are using.

Human-Approved Products:

Penicillin G (aqueous) Potassium Powder for Injection 1, 000, 000 units in vials, 5, 000, 000 unitsin vials, 10, 000, 000 units in vials, 20, 000, 000 units/vial (Rx) Penicillin G Potassium®(Apothecon); Pfizerpen® (Roerig) (Rx)
Penicillin G (aqueous) Potassium Premixed Frozen Injection: 1, 000, 000 units, 2, 000, 000 units& 3, 000, 000 units in 50 mls Penicillin G Potassium® (Baxter) (Rx)
Penicillin G (aqueous) Sodium Powder for Injection 5 million Units/vial; Penicillin G Sodium®(Apothecon) (Rx)
Penicillin G Potassium Oral Tablets 200, 000 Units, 250, 000 Units, 400, 000 Units, 500, 000
Units, 800, 000 Units; Penicillin G Potassium® (Rugby) (Rx); Pentids '400'® (Apothecon)(Rx); Pentids '800'® (Apothecon) (Rx); generic, (Rx)
Penicillin G Potassium Oral Powder for Suspension 400, 000 Units/5 ml in 100 ml and 200 ml;
Pentids '400' for Syrup® (Apothecon) (Rx)
Penicillin G (aqueous) Procaine for Injection 300, 000 Units/ml in 10 ml vials, 500, 000 Units/ml(600, 00 units/1.2 ml) in 12 ml vials, 600, 000 Units/unit dose in 1 ml Tubex, 1.2 million
Units/unit dose in 2 ml Tubex &, 2.4 million Units/unit dose in 4 ml syringes; Crysticillin 300
A.S.® (Apothecon); Pfizerpen-AS® (Roerig); Crysticillin 600 A.S.® (Apothecon); Wycillin®(Wyeth-Ayerst); (Rx)
Penicillin G Benzathine for Injection 300, 000 Units/ml in 10 ml vials; 600, 000 unit/dose in 1 ml
Tubex; 1, 200, 000 units/dose in 2 ml Tubex; 2, 400, 000 units/dose in 4 ml syringes; Bicillin L-A® (Wyeth-Ayerst); Permapen® (Roerig) (Rx)
Penicillin G Benzathine & Procaine Combined for Injection 300, 000 units/ml (150, 000 unitseach penicillin G benzathine & penicillin G procaine) in 10 ml vials; 600, 000 units/dose(300, 000 units each penicillin G benzathine & penicillin G procaine) in 1 ml Tubex; 1, 200, 000units/dose in 2 ml Tubex; 2, 400, 000 units/dose in 4 ml syringe; 900, 000 units penicillin Gbenzathine and 300, 000 units penicillin G procaine per dose in 2 ml Tubex; Bicillin C-R®(Wyeth-Ayerst); Bicillin C-R 900/300® (Wyeth-Ayerst) (Rx)

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