APRAMYCIN SULFATE
Chemistry - An aminocyclitol antibiotic produced from Streptomyces tenebrarius, apramycin is water soluble.
Pseudomonas, Salmonella, Klebsiella, Proteus, Pasturella, Treponema hyodysenteriae, Bordetellabronchiseptica), Staphylococcus and Mycoplasma. Its mechanism of action is by preventingprotein synthesis by susceptible bacteria, presumably by binding to the 30S ribosomal subunit.
Uses, Indications - Apramycin is approved for the treatment of porcine colibacillosis secondary to
E. coli sensitive to the drug. Although not approved, it has also been used for the same indication incalves. The injectable form of the drug, which is not available in the United States, has also beenused to treat gram negative infections in various species.
Absorbed drug is eliminated via the kidneys unchanged.
Drug Interactions, Drug/Laboratory Interactions - None listed. May have similar interactionpotential as neomycin; refer to that monograph for more information.
Storage, Stability, Compatibility
Apramycin powder should be stored in a cool dry place, intightly closed containers; protect from moisture. If exposed to rust, as in a rusty waterer, the drugcan be inactivated. The manufacturer recommends preparing fresh water daily.Pharmacology - APRAMYCIN SULFATE
Apramycin is bactericidal against many gram negative bacteria (E. coli,Pseudomonas, Salmonella, Klebsiella, Proteus, Pasturella, Treponema hyodysenteriae, Bordetellabronchiseptica), Staphylococcus and Mycoplasma. Its mechanism of action is by preventingprotein synthesis by susceptible bacteria, presumably by binding to the 30S ribosomal subunit.
Uses, Indications - Apramycin is approved for the treatment of porcine colibacillosis secondary to
E. coli sensitive to the drug. Although not approved, it has also been used for the same indication incalves. The injectable form of the drug, which is not available in the United States, has also beenused to treat gram negative infections in various species.
Pharmacokinetics - APRAMYCIN SULFATE
After oral administration, apramycin is partially absorbed, particularly inneonates. Absorption is dose related and decreases substantially with the age of the animal.Absorbed drug is eliminated via the kidneys unchanged.
Contraindications, Precautions, Reproductive Safety
When used as labeled, the manufacturerdoes not list any contraindications. The drug apparently has a wide margin of safety when usedorally and is safe to use in breeding swine.Adverse Effects, Warnings
When used as labeled, the manufacturer does not list any adversereactions. Should substantial amounts of the drug be absorbed, both ototoxicity and nephrotoxicityare a distinct possibility.Drug Interactions, Drug/Laboratory Interactions - None listed. May have similar interactionpotential as neomycin; refer to that monograph for more information.