Doses - ERYTHROMYCIN, ERYTHROMYCIN ESTOLATE, ERYTHROMYCIN ETHYLSUCCINATE, ERYTHROMYCIN LACTOBIONATE, ERYTHROMYCIN GLUCEPTATE

Dogs:

For susceptible infections:
a) 5 - 20 mg/kg PO q8h (Ford and Aronson 1985)
b) 10 mg/kg PO tid (Morgan 1988)
c) 10 mg/kg PO q8h (Kirk 1989)
d) 12 - 22 mg/kg PO q8h (Aronson and Aucoin 1989)

Cats:

For susceptible infections:
a) 5 - 20 mg/kg PO q8h (Ford and Aronson 1985)
b) 15 mg/kg PO q8h (Jenkins 1987b)
c) 10 mg/kg PO tid (Morgan 1988)
d) 10 mg/kg PO q8h (Kirk 1989)
e) 12 - 22 mg/kg PO q8h (Aronson and Aucoin 1989)

Birds:

For susceptible infections:
a) Oral suspension: 60 mg/kg PO q12h (Hoeffer 1995)

Cattle:

For susceptible infections:
a) 4 - 8 mg/kg IM q12-24h (Jenkins 1987b)
b) For bronchopneumonia and fibrinous pneumonia in cattle associated with bacteriasensitive to erythromycin and resistant to sulfas, penicillin G and tetracyclines: Using
Erythro-200®: 44 mg/kg IM q24h usually for a maximum of 4 days. Inject no morethan 10 ml at any one site. Do not inject at any site previously used. Severe local tissuereactions may occur. Recommend a 30 day slaughter withdrawal at this dosage. (Hjerpe1986)
For mastitis:
a) Dry cow (using dry cow formula): Milk out affected quarter, clean and disinfect. Infusecontents of one syringe into each affected quarter at time of drying off. Close teat orificewith gentle pressure and massage udder.
Lactating cow (using lactating cow formula): As above, but repeat after each milking for3 milkings. (Label directions; Erythro®-Dry & Erythro®-36¯Ceva)

Horses:

For treatment of C. (Rhodococcus) equi infections in foals:
a) Erythromycin estolate or ethylsuccinate: 25 mg/kg PO tid with rifampin: 5 mg/kg PO tid. (Hillidge and Zertuche 1987)
b) Erythromycin estolate: 25 mg/kg PO q6h
Erythromycin gluceptate: 5 mg/kg IV q4-6h (Caprile and Short 1987)
c) Erythromycin estolate: 25 mg/kg PO qid
Erythromycin gluceptate: 5 mg/kg IV 4-6 times daily
Erythromycin base (veterinary) injectable: 10 mg/kg IM bid (Prescott, Hoover, and Dohoo 1983)
For susceptible infections:
a) Erythromycin estolate: 25 mg/kg PO q6h
Erythromycin ethylsuccinate: 25 mg/kg PO q8h
Erythromycin gluceptate: 5 mg/kg IV q4-6h
Erythromycin lactobionate: 3 - 5 mg/kg IV q6-8h (Brumbaugh 1987)

Swine:

For susceptible infections:
a) For respiratory infections: 2.2 - 6.6 mg/kg IM once daily
For scours in young pigs: 22 mg/kg IM in one or more daily doses. (Label directions;
Erythro®-100 & Erythro®-200¯Ceva)

Sheep:

For susceptible infections:
For respiratory infections in older animals: 2.2 mg/kg IM once daily as indicated.
For prevention of "dysentery" in newborn lambs when the likely causative agent is susceptible to erythromycin: 123 mg/kg IM once soon after birth. (Label directions;
Erythro®-100 & Erythro®-200¯Ceva)
Monitoring Parameters -

1) Clinical efficacy

2) Adverse effects (periodic liver function tests if patient receiving erythromycin estolate long-term; may not be necessary for foals receiving erythromycin and rifampin for Rhodococcus infections)
Client Information - The intramuscular 100 mg/ml (Erythro-100®) & 200 mg/ml products (Erythro-200®) have quite specific instructions on where and how to inject the drug. Refer to the label directions or package insert for more information before using.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Erythromycin 100 mg/ml for IM Injection (with 2% butyl aminobenzoate as a local anesthetic) in 100 ml vials
Erythro-100® (Rhone Merieux); (OTC) Approved for use in dogs, cats, cattle, sheep, and swine. Milk withdrawal = 72 hours. Slaughter withdrawal for cattle, sheep, swine = 48 hours.
Erythromycin 200 mg/ml for IM Injection in 100 ml, 250 ml, and 500 ml vials
Erythro-200® (Rhone Merieux); (OTC) Approved for use in cattle, sheep, and swine. Milk withdrawal = 72 hours. Slaughter withdrawal for cat le =14 days (21 days to avoid excessive trimming). Slaughter withdrawal for sheep = 3 days (10 days to avoid excessive trimming). Slaughter withdrawal for swine = 7 days (10 days to avoid excessive trimming).
Erythromycin Mastitis Infusion Tube for Dry Cows; 600 mg erythromycin per 12 ml tube
Erythro®-Dry (Rhone Merieux); (OTC) Approved for use in dry dairy cattle. Milk withdrawal = 36 hours. Slaughter withdrawal = 14 days nor within 96 hours of calving. Calvesborn to treated cows may not be slaughtered for food at less than 10 days of age.
Erythromycin Mastitis Infusion Tube for Lactating Cows; 50 mg/ml of erythromycin per 6 mltube
Erythro®-36 (Rhone Merieux); (OTC) Approved for use in dry dairy cattle. Milk withdrawal= 36 hours. Slaughter withdrawal = 14 days.
There are also several erythromycin premixes alone and in combination with other drugs for usein swine and/or poultry.

Human-Approved Products:

Erythromycin Base Oral Tablets enteric-coated 250 mg, 500 mg; Ery-Tab® (Abbott); E-Mycin®(Boots), Robimycin® Robitabs® (Robins);E-Base® (Barr); (Rx)
Erythromycin Base Oral Tablets film-coated 250 mg, 500 mg
Erythromycin Film-Tabs® (Abbott); (Rx)
Erythromycin Base Oral Capsules delayed release enteric-coated pellets 250 mg; Eryc® (Parke-Davis); (Rx)
Erythromycin Base Delayed Relased Tablets 333 mg, generic, (Rx)Erythromycin Base Tablets with polymer coated particles 500 mg; PCE Dispertab ® (Abbott) (Rx)
Erythromycin Base Oral Capsules delayed release 250 mg; generic (Rx)Erythromycin Estolate Tablets 500 mg (as estolate) Ilosone® (Dista) (Rx)
Erythromycin Estolate Capsules 250 mg (as estolate); Ilosone Pulvules® (Dista) (Rx); generic, (Rx)
Erythromycin Estolate Suspension: 125 mg (as estolate) per 5 ml in 480 mls and 250 mg (asestolate) per 5 ml in 100 & 480 mls; Ilosone® (Dista); generic, (Rx)
Erythromycin Stearate Film-coated tablets 250 mg, 500 mg; generic; (Rx)
Erythromycin Ethylsuccinate Chewable Tablets: 200 mg (as ethylsuccinate; equiv. to 125 mg of base); EryPed® (Abbott) (Rx)
Erythromycin Ethylsuccinate Tablets: 400 mg (as ethylsuccinate); E.E.S. 400; generic, (Rx)
Oral Suspension: 40 mg/ml (equiv. to 25 mg/ml base), 80 mg/ml (equiv. to 50 mg/ml base) in 100, 200, 480, and 500 ml bottles; 100 mg per 2.5 ml in 50 mls, 200 & 400 mg (as ethylsuccinate) per 5 ml in 60, 100, 200 and 480 ml and UD 5 ml (100's); EryPed Drops®(Abbott); EryPed 400® (Abbott); E.E.S. 400; generic (Rx)
Powder for Oral Suspension: 200 mg (as ethylsuccinate) per 5 ml when reconstituted in 100 &200 mls ; E.E.S. Granules® (Abbott) (Rx)
Granules for Oral Suspension: 400 mg (as ethylsuccinate) per 5 ml when reconstituted; EryPed
Drops ® (Abbott)
Erythromycin Lactobionate Powder for Injection: 500 mg & 1 g (as lactobionate); generic (Rx)
Erythromycin Lactobionate Injection: 1 g erythromycin (as gluceptate) per vial in 30 mls;
Ilotycin Gluceptate® (Dista) (Rx)