Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

Doses - BUSULFAN

Small Animals:
For chronic granulocytic leukemias (not during "blastic" phase¯of no benefit): 3 -4mg/m2 PO once daily. Discontinue when total white blood cell count reaches approximately 15, 000. Repeat as necessary. May require up to two weeks to observe a positive response. If there is too rapid a decline in total WBC's, discontinue drug. (Jacobs,
Lumsden et al. 1992)
Monitoring Parameters - 1) CBC; 2) Serum uric acid; 3) Efficacy
Client Information - Clients must understand the importance of both administering busulfan asdirected and to report immediately any signs associated with toxicity (e.g., abnormal bleeding, bruising, urination, depression, infection, shortness of breath, etc.).
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Busulfan Oral Tablets (scored) 2 mg; Myleran® (Glaxo Wellcome); (Rx)
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