Doses - TYLOSIN
Dogs: 
For susceptible infections: a) 6.6 - 11 mg/kg IM q12-24h (Ford and Aronson 1985)
b) For chronic colitis: Tylan® Plus Vitamins: 40 - 80 mg/kg/day in 2-3 divided doses;either mixed with food (tastes bitter) or as a bolus mixed with water. Use at recommended dose for 2 weeks and then gradually taper as animal's diet is adjusted. Someanimals may require long-term therapy. (Chiapella 1986)
c) For chronic colitis: Tylan® Plus Vitamins: 20 - 40 mg/kg bid; mixed with food (tastes bitter).
May alternate with sulfasalazine for long-term maintenance therapy. (DeNovo 1988)
Note: Tylan® plus Vitamins has recently been discontinued by the manufacturer. Tylan® Soluble
Powder » 4, 000 mg/teaspoonsful may be substituted, but this product is much more concentratedand may require dilution for accurate dosing.
Cats: 
For susceptible infections: a) 6.6 - 11 mg/kg IM q12-24h (Ford and Aronson 1985)
b) 10 mg/kg IM q12h (Jenkins 1987b)
c) For chronic colitis: Tylan® Plus Vitamins (approximately 470 mg/teaspoonful): 10 - 20mg/kg/day in 2 divided doses; either mixed with food (tastes bitter) or as a bolus mixed with water.
Use at recommended dose for 2 weeks and then gradually taper as animal's diet is adjusted. Someanimals may require long-term therapy. (Chiapella 1986)
d) For chronic colitis: Tylan® Plus Vitamins (approximately 400 mg/teaspoonful): 5 - 10 mg/kgbid; mixed with food (tastes bitter). May alternate with sulfasalazine for long-term maintenancetherapy. (DeNovo 1988)
Note: Tylan® plus Vitamins has recently been discontinued by the manufacturer. Tylan® Soluble
Powder » 4, 000 mg/teaspoonsful may be substituted, but this product is much more concentratedand may require dilution for accurate dosing.
Cattle: 
For susceptible infections: a) 17.6 mg/kg IM once daily. Continue treatment for 24 hours after symptoms have stopped, not toexceed 5 days. Do not inject more than 10 ml per site. Use the 50 mg/ml formulation in calvesweighing less than 200 pounds. (Package insert; Tylosin Injection¯TechAmerica)
b) For bronchopneumonia and fibrinous pneumonia in cattle associated with penicillin G-refractory
C. pyogenes infections or other bacteria sensitive to tylosin and resistant to sulfas, penicillin G andtetracyclines: using Tylosin 200 mg/ml : 44 mg/kg IM q24h. Recommend a 21 day slaughterwithdrawal at this dosage. (Hjerpe 1986)
c) 5 - 10 mg/kg IM or slow IV once daily; not to exceed 5 days. (Huber 1988a)
d) Tylosin base injectable: 10 mg/kg IM initially, then 6 mg/kg IM q8h (q8-12h in calves). (Baggot 1983)
Swine: 
For susceptible infections: a) 8.8 mg/kg IM twice daily. Continue treatment for 24 hours after symptoms have stopped, not toexceed 3 days. Do not inject more than 5 ml per site. (Package insert; Tylosin
Injection¯TechAmerica)
b) 5 - 10 mg/kg until 24 hours after remission of disease signs; not to exceed 3 days therapy.(Huber 1988a)
c) Tylosin base injectable: 12.5 mg/kg IM q12h. (Baggot 1983)
Sheep & Goats:
For susceptible infections: a) 10 mg/kg, treatment not to exceed 5 days. (Huber 1988a)
Birds: 
For susceptible infections: a) For initial therapy in caged birds for upper respiratory infections (especially if mycoplasmasuspected).
Using 200 mg/ml injectable: 40 mg/kg IM. Used in combination with aminoglycosides.
Using Tylan® Plus Vitamins: 1/4 teaspoonsful per 8 oz of drinking water. (McDonald 1989)
b) For initial therapy of upper respiratory infections and air sacculitis. Using 50 mg/ml or 200mg/ml injectable: 10 - 40 mg/kg IM bid or tid.
For chronic respiratory disease using Tylan® Plus Vitamins: 2 teaspoonsful per gallon ofdrinking water. 10 days on, 5 days off, and 10 days on. Tastes bitter. May divide dosage betweenfood and water. (Clubb 1986)
c) 30 mg/kg IM q12h (Hoeffer 1995)
Reptiles: 
For susceptible infections: a) For tortoises: 5 mg/kg IM once daily for at least 10 days. Used primarily for chronic respiratoryinfections or when Mycoplasma is suspected (Gauvin 1993)
Monitoring Parameters -
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Tylosin Injection 50 mg/ml, 200 mg/ml; Tylan® (Elanco), generic; (OTC) Approved for use innonlactating dairy cat le, beef cattle, swine, dogs, and cats. Slaughter withdrawal = cattle 21 days;swine 14 days.(Note: Although this author was unable to locate parenteral products approved for use in lactatingdairy animals, one source (Huber 1988a) states that tylosin has a 72 hour milk withdrawal for dairycattle, and 48 hour milk withdrawal in dairy goats and sheep.)
Tylosin tartrate (approximately 4000 mg/teaspoonsful) in 100 g bottles; Tylan®Soluble (Elanco);(OTC) Approved for use in turkeys (not layers), chickens (not layers) and swine. Slaughterwithdrawal swine = 2 days; chickens = 1 day; turkeys = 5 days.
There are many approved tylosin products for addition to feed or water for use in beef cattle, swine, and poultry. Many of these products also have other active ingredients included in theirformulations.
Human-Approved Products: None.