Doses - TRIMEPRAZINE TARTRATE, TRIMEPRAZINE TARTRATE WITH PREDNISOLONE

Trimeprazine:
a)In general, for all species, all routes: 1.1 - 4.4 mg/kg qid (Swinyard 1975)

Dogs:

a) 2.5 mg/10 lbs up to 40 pounds; for patients over 40 lb.: 15 mg bid, after 4 days, reduce the dose to 1/2 of the initial dose (Swinyard 1975)
Trimeprazine/Prednisolone (Temaril®-P):

Dogs:

Give capsules once daily PO, and tablets bid PO; after 4 days reduce dose to 1/2 of initial dose; adjust as necessary. (Package Insert; Temaril®-P - SKB)
Monitoring Parameters -

1) Efficacy

2) Degree of sedation, and anticholinergic effects

3) Adverse effects associated with corticosteroids if using combination product
Client Information - Trimeprazine is approved for use in humans and is a prescription drug.
Trimeprazine in combination with prednisolone is approved for use in dogs only and is a veterinary prescription drug.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
No single agent trimeprazine products are approved for veterinary medicine.
Trimeprazine Tartrate 5 mg; Prednisolone 2 mg Tablets; Temaril-P® Tablets (Pfizer); (Rx)
Approved for use in dogs.
Human-Approved Products: None
Trimethoprim/Sulfa - See Sulfa/Trimethoprim