Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

NANDROLONE DECANOATE

Chemistry - An injectable anabolic steroid, nandrolone decanoate occurs as a white, to creamywhite, crystalline powder. It is odorless or may have a slight odor and melts between 33-37°C.
Nandrolone decanoate is soluble in alcohol and vegetable oils and is practically insoluble in water.
The commercially available injectable products are generally solutions dissolved in sesame oil.

Storage, Stability, Compatibility

Nandrolone decanoate for injection should be stored at temperatures less than 40°C and preferably between 15-30°C; protect from freezing and protect from light.

Pharmacology - NANDROLONE DECANOATE

Nandrolone exhibits similar actions as other anabolic agents. For more information refer to the preceding monograph (Boldenone).
Many veterinary and human clinicians feel that nandrolone is clinically superior to other anabolicsin its ability to stimulate erythropoiesis. It is believed that nandrolone may enhance red cel countsby directly stimulating red cel precursors in the bone marrow, increasing red cell 2, 3-diphosphoglycerate and increasing erythropoietin production in the kidney.
Uses, Indications - The principle use of nandrolone in veterinary medicine has been to stimulateerythropoiesis in patients with certain anemias (e.g., secondary to renal failure, aplastic anemias). Ithas also been suggested to be used as an appetite stimulant.

Pharmacokinetics - NANDROLONE DECANOATE

No specific information was located for this agent. It is generally recommended for both small animals and humans to be dosed on a weekly basis.
Contraindications/Precautions - No specific recommendations were located for this agent inveterinary species.
In humans, anabolic agents are also contraindicated in patients with hepatic dysfunction, hypercalcemia, patients with a history of myocardial infarction (can cause hypercholesterolemia), pituitaryinsufficiency, prostate carcinoma, in selected patients with breast carcinoma, benign prostatichypertrophy and during the nephrotic stage of nephritis.
The anabolic agents are category X (risk of use outweighs any possible benefit) agents for use inpregnancy and are contraindicated because of possible fetal masculinization.

Adverse Effects, Warnings

Potential (from human data) adverse reactions of the anabolic agentsin dogs and cats include: sodium, calcium, potassium, water, chloride and phosphate retention;hepatotoxicity, behavioral (androgenic) changes and reproductive abnormalities (oligospermia, estrus suppression).
Overdosage - No information was located for this specific agent. In humans, sodium and waterretention can occur after overdosage of anabolic steroids. It is suggested to treat supportively andmonitor liver function should an inadvertent overdose be administered.

Drug Interactions

Anabolic agents as a class may potentiate the effects of anticoagulants.
Monitoring of PT's and dosage adjustment, if necessary of the anticoagulant are recommended.
Diabetic patients receiving insulin may need dosage adjustments if anabolic therapy is added ordiscontinued. Anabolics may decrease blood glucose and decrease insulin requirements.
Anabolics may enhance the edema that can be associated with ACTH or adrenal steroid therapy.
Drug/Laboratory Interactions - Concentrations of protein bound iodine (PBI) can be decreased in patients receiving androgen/anabolic therapy, but the clinical significance of this is probably not important. Androgen/anabolic agents can decrease amounts of thyroxine-binding globulin and decrease total T4 concentrations and increase resin uptake of T3 and T4. Free thyroid hormones are unaltered and, clinically, there is no evidence of dysfunction.
Both creatinine and creatine excretion can be decreased by anabolic steroids. Anabolic steroidscan increase the urinary excretion of 17-ketosteroids.
Androgenic/anabolic steroids may alter blood glucose levels. Androgenic/-anabolic steroids maysuppress clotting factors II, V, VII, and X. Anabolic agents can affect liver function tests (BSPretention, SGOT, SGPT, bilirubin, and alkaline phosphatase).

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