Doses - CHLOROTHIAZIDE, CHLOROTHIAZIDE SODIUM

Dogs:

For treatment of nephrogenic diabetes insipidus:
a) 20 - 40 mg/kg PO q12h (Polzin and Osborne 1985), (Nichols 1989)
For treatment of systemic hypertension:
a) 20 - 40 mg/kg PO q12-24h with dietary salt restriction (Cowgill and Kallet 1986)
As a diuretic:
a) 10 - 40 mg/kg PO bid (Morgan 1988)

Cattle:

a) 4 - 8 mg/kg once or twice daily PO for adult cattle (Howard 1986)
b) 2 grams PO once or twice daily for 3 - 4 days ( Package Insert ¯ Diuril® Boluses;
MSD)
c) 2 grams PO once to twice daily (Swinyard 1975)
Monitoring Parameters -

1) Serum electrolytes, BUN, creatinine, glucose

2) Hydration status

3) Blood pressure, if indicated

4) Hemograms, if indicated
Client Information - Clients should contact veterinarian if symptoms of water or electrolyte imbalance occur. Symptoms such as excessive thirst, lethargy, lassitude, restlessness, oliguria, GI distress or tachycardia may indicate electrolyte or water balance problem.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Chlorothiazide Tablets 250 mg, 500 mg; Diuril® (Merck); Diurigen® (Goldline); Generic; (Rx)Chlorothiazide Oral Suspension 50 mg/ml in 237 ml bottles; Diuril® (Merck); (Rx)Chlorothiazide Sodium Powder for Injection 500 mg vial; Diuril® Sodium (Merck); (Rx)