Doses - ACETAZOLAMIDE SODIUM

Directions for reconstitution of injection: Reconstitute 500 mg vial with at least 5 ml of
Sterile Water for Injection; use within 24 hours after reconstitution.

Dogs:

For adjunctive treatment of metabolic alkalosis:
a) 10 mg/kg qid (may aggravate volume contraction and hypokalemia). (Hardy and Robinson 1986)
For adjunctive therapy of glaucoma:
a) 10 - 25 mg/kg divided 2-3 times daily (Brooks 1986)
b) 10 - 30 mg/kg divided tid (Wyman 1986)
c) 50 mg/kg IV one time; 7 mg/kg PO tid (Vestre 1985)

Cats:

For adjunctive therapy of glaucoma:
a) 50 mg/kg IV once; 7 mg/kg PO tid (Vestre 1985)

Ruminants:

a) 6 - 8 mg/kg IV, IM, or SQ (Howard 1986)

Swine:

a) 6 - 8 mg/kg IV, IM, or SQ (Howard 1986)
Monitoring Parameters -

1) Intraocular pressure/tonometry (if used for glaucoma); blood gases if used for alkalosis;

2) Serum electrolytes;

3) Baseline CBC with differential and periodic retests if using chronically;

4) Other adverse effects
Client Information - If using oral preparation and GI upset occurs, give with food. Notify veterinarian if abnormal bleeding or bruising occurs or if animal develops tremors or a rash.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Acetazolamide 125 mg, 250 mg Tablets; Diamox® (Lederle) (Rx); .i.Dazamide® (Major) (Rx);generic (Rx)
Acetazolamide Extended-release Capsules 500mg; Diamox Sequels® (Lederle); generic (Rx)Acetazolamide Injection: 500 mg per vial; Diamox®; (Lederle);Acetazolamide Powder 500 mg for Reconstitution; Diamox® (Lederle); Generic; (Rx)
To prepare parenteral solution: Reconstitute with at least 5 ml of Sterile Water for Injection. Ifrefrigerated, potency will remain for 1 week, but it should be used within 24 hours as it contains no preservatives.