Doses - COLCHICINE
Colchicine may have some efficacy in the treatment of amyloidosis, but veterinary dosages areapparently unavailable at this time.Dogs:
For the adjunctive treatment of hepatic cirrhosis/fibrosis:
a) 0.025 - 0.03 mg/kg/day PO. Benefit is unproven. (Johnson and Sherding 1994)
b) 0.025 mg/kg PO per day; more evaluation on efficacy needed. (Rutgers 1994)
c) 0.03 mg/kg PO once daily (Leveille-Webster and Center 1995)
Monitoring Parameters - 1) Efficacy; 2) Adverse Effects (see above); 3) CBC
Client Information - Clients should be informed of the "investigational" nature of colchicine usein dogs and should be informed of the potential adverse effects that may be seen. They shouldreport changes in appetite or other GI effects immediately.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None
Colchicine Injection 0.5 mg/ml in 2 ml amps; (Lilly); (Rx)
Co-Trimoxazole; Co-trimazine ¯ See Sulfa/Trimethoprim
Dogs: 
For the adjunctive treatment of hepatic cirrhosis/fibrosis: a) 0.025 - 0.03 mg/kg/day PO. Benefit is unproven. (Johnson and Sherding 1994)
b) 0.025 mg/kg PO per day; more evaluation on efficacy needed. (Rutgers 1994)
c) 0.03 mg/kg PO once daily (Leveille-Webster and Center 1995)
Monitoring Parameters - 1) Efficacy; 2) Adverse Effects (see above); 3) CBC
Client Information - Clients should be informed of the "investigational" nature of colchicine usein dogs and should be informed of the potential adverse effects that may be seen. They shouldreport changes in appetite or other GI effects immediately.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None
Human-Approved Products:
Colchicine Tablets 0.5 mg, 0.6 mg;Colchicine® (Abbott) (Rx); Generic; (Rx)Colchicine Injection 0.5 mg/ml in 2 ml amps; (Lilly); (Rx)
Co-Trimoxazole; Co-trimazine ¯ See Sulfa/Trimethoprim