FIPRONIL

Chemistry/Storage, Stability, Compatibility

Fipronil is a phenylpyrazole antiparasitic agent.
The commercially available topical products should be stored at room temperature, unless otherwisedirected by the manufacturer. Commercially available solutions are flammable; keep away from heatand open flame.

Pharmacology - FIPRONIL

Fipronil's mechanism of action in invertebrates is to interfere with the passage ofchloride ions in GABA regulated chloride channels, thereby disrupting CNS activity.

Uses, Indications

In the USA, Fipronil is indicated for the treatment of fleas and ticks in dogsand cats. It may be of use in other species as well, but available safety and efficacy data is notreadily accessible.

Pharmacokinetics - FIPRONIL

The manufacturer states that fipronil collects in the oils of the skin and hairfollicles and continues to be released over a period a time resulting in long residual activity.
Topically applied, the drug apparently spreads over the body in approximately 24 hours viatranslocation.

Contraindications, Precautions, Reproductive Safety

Do not use on kittens less than 12weeks of age and on puppies less than 10 weeks old. While temporary irritation may occur at thesite of administration, animals who have demonstrated sensitivity reactions to fipronil or any of theingredients in the products, should probably not be retreated.
The manufacturer warns that the product may be harmful to debilitated, aged, pregnant, or nursinganimals.

Adverse Effects, Warnings

Rarely, hypersensitivity has been reported. Temporary irritation mayoccur at the site of administration.
Overdosage - No adverse effects have been reported in studies where 5X the maximum dose wasadministered to dogs and cats. Dogs fed 640 mg/kg and cats fed 320 mg/kg of fipronil showed nosignificant adverse effects.

Drug Interactions

Although the manufacturer does not list any known drug interactions, it warnsthat certain medications can interact with insecticides.