Doses - IMIPENEM-CILASTATIN SODIUM

Dogs & Cats:

For susceptible infections:
a) 2 - 5 mg/kg IV q6-8h (avoid or reduce dose in animals with severe renal failure) (Vaden and Papich 1995)
b) 2 - 5 mg/kg every 8 hours (tid) (Lappin 1997)
Horses:For susceptible infections: 15 mg/kg IV (over a 20 minute period) q 4- 6 hours (Walker 1992)
Monitoring Parameters - 1) Efficacy; 2) Adverse effects (including renal and hepatic function tests if treatment is prolonged or patient's renal or hepatic function are in question)
Client Information - Imipenem/cilastatin should be administered in an inpatient setting. Clients should be informed of the cost of using this medication.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Imipenem:Cilastatin Parenteral for Injection for IV infusion: 250 mg:250 mg (with 10 mgsodium bicarbonate), 500 mg:500 mg (with 20 mg sodium bicarbonate); Primaxin® I.V.(Merck); (Rx)
Imipenem:Cilastatin Suspension for IM Injection: 500 mg:500 mg, 750 mg:750 mg; Primaxin®
I.M. (Merck); (Rx)