CLIOQUINOL
Chemistry - Also known as iodochlorhydroxyquin, clioquinol possesses antibacterial, antifungaland amoebicidal activity. It occurs as a tasteless, voluminous, yellowish white to brownish yellowpowder that has a slight characteristic odor. The drug is practically insoluble in water and alcohol.
Iodism or potentially neurotoxic reactions (see Adverse effects above) could result.
Drug Interactions; Drug/Laboratory Interactions - None located, but the iodine component ofthe drug may affect some thyroid function tests.
Storage, Stability, Compatibility
Unless otherwise directed, store clioquinol boluses at roomtemperature and protect from light.Pharmacology - CLIOQUINOL
Information on the mechanism of action of clioquinol was not located, but itsaction is probably due to its iodine content. It is reportedly active against some cocci, E. coli, yeasts, and some protozoal parasites, particularly Trichomonas sp..Uses, Indications
Clioquinol boluses are approved for oral use in horses to treat diarrheas thathave failed to respond to regular forms of treatment, particularly if caused by some protozoal organisms. Clioquinol was once used orally in humans to treat diarrhea, but severe neurotoxic reactions have eliminated its use in humans, except as a topical antifungal.Pharmacokinetics - CLIOQUINOL
The drug is only minimally absorbed after oral administration in horses. Noother information was noted.Contraindications, Precautions, Reproductive Safety
Not to be used in horses intended forfood. No other information located.Adverse Effects, Warnings
The manufacturer does not list any adverse effects for this productwhen used orally in horses. In humans, subacute myelo-opticoneuropathy was seen in many patients taking the drug orally for prolonged periods of time. It is unknown if the drug causes neurotoxic effects in horses. Topical administration for 28 days of the 3% topical preparation hascaused toxicity in dogs.Overdosage, Acute Toxicity
No specific information located regarding overdosage in horses.Iodism or potentially neurotoxic reactions (see Adverse effects above) could result.
Drug Interactions; Drug/Laboratory Interactions - None located, but the iodine component ofthe drug may affect some thyroid function tests.