Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.



GnRH challenge to test pituitary sufficiency or testicular steroidogenesis:
a) 125 - 250 ng/kg (refer to reference for more information) (Amann 1986)
To aid in the descent of cryptorchid testes:
a) 50 - 100 micrograms SQ or IV; if no response give additional dose in 4-6 days (Cox1986)


To stimulate ovulation after mating:
a) 25 micrograms IM after mating (Morgan 1988)


To treat of ovarian cysts in cattle:
a) 100 micrograms IM or IV (Package Insert; Cystorelin®¯Ceva)
b) 100 micrograms IM per cow (Package insert; Factrel®¯Fort Dodge)

Sheep & Goats:

To induce ovulation outside of the breeding season in the doe:
a) 100 micrograms injected daily for 4-5 days (Smith 1986b)
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Gonadorelin (diacetate tetrahydrate) for Injection 50 micrograms/ml, 2 ml single-use or 10 mlmulti-dose vials; Cystorelin® (Rhone Merieux); Fertagyl® (Intervet); (Rx) Approved for usein dairy cattle. There are no withdrawal times required for either milk or slaughter.
Gonadorelin HCl Solution for Injection 50 mcg/ml in 2 ml single-use, and 20 ml multi-dosevials; Factrel® (Fort Dodge); (Rx) Approved for use in cattle. No withdrawal period required.

Human-Approved Products:

Gonadorelin Acetate Powder for Injection (lyophilized) 0.8 and 3.2 mg in 10 ml vials;
Lutrepulse® (Ferring) (Rx)
Gonadorelin HCl Powder for Injection 100 mcg/vial, 500 mcg/vial; Factrel® (Wyeth-Ayerst); (Rx)