IMIDOCARB DIPROPINATE
Chemistry/Storage, Stability, Compatibility
Imidocarb dipropinate is a diamidine of the carbanalide series of antiprotozoal compounds. The injection should be stored between 2°-25°C (36°- 77°F) and protected from light.Pharmacology - IMIDOCARB DIPROPINATE
Imidocarb is thought to act by combining with nucleic acids of DNA in susceptible organisms, causing the DNA to unwind and denature. This damage to DNA is believed to inhibit cellular repair and replication.Uses, Indications - Imidocarb is approved for use to treat Babesia canis infections (babesiosis) indogs, but the drug may also be efficacious against Ehrlichia canis in this species. Imidocarb mayalso be of benefit in treating Babesia and related parasitic diseases in a variety of domestic andexotic animals.
Imidocarb appears to be more effective against B. canis than B. gibsoni.
Pharmacokinetics - IMIDOCARB DIPROPINATE
No specific information was located for this drug.Contraindications, Precautions, Reproductive Safety
Do not use imidocarb in patients exposed to cholinesterase-inhibiting drugs, pesticides or chemicals.Safety in puppies, pregnant, lactating or breeding animals has not been established; manufacturer states to consider risk versus benefit before treating dogs with impaired lung, hepatic or renal function.
Adverse Effects, Warnings
Most common reported adverse effects in dogs include pain duringinjection and mild cholinergic signs (salivation, nasal drip and brief episodes of vomiting). Lesscommon reported effects include panting, diarrhea, injection site inflammation (rarely ulceration)and restlessness. Imidocarb has reportedly caused an increase incidence of tumor formation in rats.Do not administer intravenously.
Overdosage - Dogs receiving a dosage of 9.9 mg/kg (1.5X labeled dose) showed signs of liverinjury (slightly increased liver enzymes), pain and swelling at the injection site, and vomiting.
Overdoses or chronic toxicity may present with cholinergic signs (vomiting, weakness, lethargy, salivation) or adverse changes in liver, kidney, lung or intestinal function. Treatment with atropinemay be useful to treat cholinergic signs associated with imidocarb.