Doses - CLINDAMYCIN HCL, CLINDAMYCIN PALMITATE HCL, CLINDAMYCIN PHOSPHATE

Dogs:

For susceptible infections:
a) 5.5 - 11 mg/kg PO q12h; 11 -16.5 mg/kg SQ q24h (Aronson and Aucoin 1989)
b) 5 - 11 mg/kg IM, SubQ or PO q12h avoid or reduce dose in patients with severe liverfailure (Vaden and Papich 1995)
c) 10 mg/kg PO or IM q12h (Ford and Aronson 1985)
d) 5 - 10 mg/kg PO q12h (Jenkins 1987b)
For treatment of toxoplasmosis:
a) 10 - 40 mg/kg/day PO divided tid-qid. (Murtaugh 1988)

Cats:

For susceptible infections:
a) 5.5 - 11 mg/kg PO q12h; 11 -16.5 mg/kg SQ q24h (Aronson and Aucoin 1989)
b) 5 - 11 mg/kg SubQ or PO q12h (Vaden and Papich 1995)
c) 10 mg/kg PO or IM q12h (Ford and Aronson 1985)
d) 5 - 10 mg/kg PO q12h (Jenkins 1987b)
For treatment of toxoplasmosis:
a) 25 mg/kg PO divided into 2-3 doses per day for 4 weeks (Lappin 1995)
Monitoring Parameters -

1) Clinical efficacy

2) Adverse effects; particularly severe diarrheas

3) Manufacturer recommends doing periodic liver and kidney function tests and blood counts if therapy persists for more than 30 days.
Client Information - Clients should be instructed to report the incidence of severe, protracted or bloody diarrhea to the veterinarian.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products:
Clindamycin (as the HCl) Oral Capsules 25 mg, 75 mg, 150 mg
Antirobe® (Upjohn); (Rx) Approved for use in dogs.
Clindamycin (as the HCl) Oral Solution 25 mg/ml in 20 ml bottles
Antirobe® Aquadrops (Upjohn); Generic; (Rx) Approved for use in dogs.

Human-Approved Products:

Clindamycin (as the HCl) Oral Capsules 75 mg, 150 mg, 300 mg
Cleocin® (Upjohn); generic (Rx)
Clindamycin (as the palmitate HCl) Granules for oral solution 75 mg/5 ml (15 mg/ml) (as palmitate) in 100 ml bottles; Cleocin® Pediatric (Upjohn); (Rx)
Clindamycin (as the Phosphate) Injection 150 mg/ml in 2, 4, 6, and 60 ml vials 4, 6 ml ADD-Vantage vials, 50 ml Galaxy plastic containers and 60 ml pharmacy bulk packages; Cleocin®
Phosphate (Upjohn); (Rx); generic (Rx)
Also available in topical and vaginal preparations.