Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

Doses - ANTACIDS, ORAL

Dogs: Dog

For hyperphosphatemia:
a) Aluminum hydroxide: Initially at 30 - 90 mg/kg per day. Dosage must be individualized. Prefer capsules or suspension as they are more easily mixed with food and dispersed throughout ingesta. Evaluate serum phosphate levels at 10-14 days intervals todetermine optimum dosage. (Polzin and Osborne 1985)
b) Aluminum hydroxide: 30 - 90 mg/kg PO once a day to three times a day with meals(Morgan 1988)
For adjunctive therapy for gastric ulcers:
a) Aluminum hydroxide suspension or aluminum hydroxide/magnesium hydroxide suspension: 2 - 10 ml PO q2-4h (Hall and Twedt 1988)
b) Aluminum hydroxide tablets: 0.5 - 1 tablet PO q6h (Matz 1995)
As an antacid:
a) Magnesium hydroxide (Milk of Magnesia): 5 - 30 ml PO once to twice daily (Morgan1988)

Cats: Cat

For hyperphosphatemia:
a) Aluminum hydroxide: Initially at 30 - 90 mg/kg per day. Dosage must be individualized. Prefer capsules or suspension as they are more easily mixed with food and dispersed throughout ingesta. Evaluate serum phosphate levels at 10-14 days intervals todetermine optimum dosage. (Polzin and Osborne 1985)
As an antacid:
a) Magnesium hydroxide (Milk of Magnesia): 5 - 15 ml PO once to twice daily (Morgan1988)
b) Aluminum hydroxide tablets: 0.25 tablets PO q6h (Matz 1995)

Cattle: Cattle

For rumen overload syndrome:
a) For adult animals: Up to 1 gm/kg (MgOH) mixed in 2-3 gallons of warm water andgiven PO per tube. May repeat (use smaller doses) at 6-12 hour intervals. If the rumenhas been evacuated, do not exceed 225 grams initially. Dehydration and systemic acidosis must be concomitantly corrected.
Calves: As above but use 1/8th-1/4th the amount. (Wass et al. 1986a)
As an antacid:
a) Aluminum hydroxide: 30 grams;
Calcium carbonate: 60 - 360 grams (Jenkins 1988)

Horses: Horse

For adjunctive gastroduodenal ulcer therapy in foals:
a) Aluminum/magnesium hydroxide suspension: 15 ml 4 times a day (Clark and Becht1987)

Sheep & Goats:Sheep

For rumen overload syndrome:
a) As above for cattle, but use 1/8th-1/4th the amount. (Wass et al. 1986a)
Monitoring Parameters - Monitoring parameters are dependent upon the indication for theproduct and the salt used. Patients receiving high dose or chronic therapy should be monitored forelectrolyte imbalances outlined above.
Client Information/FDA Approval Status - Oral antacids are available without prescription(OTC). Most products are labeled for use in humans. There are veterinary approved products foruse in food animals.
Dosage Forms/Preparations- Veterinary-Approved Products:
Magnesium Hydroxide
Oral Boluses 27 grams of magnesium hydroxide, ginger 200 mg, capsicum 100 mg, methylsalicylate 56 mg
Magnalax® (OTC)
Oral Powder, each pound of powder contains: 350 grams of magnesium hydroxide, ginger 2.6grams, capsicum 1.3 grams, methyl salicylate 56 mg Rulax II® (OTC)
Human-Approved Products: The following is a list of some antacids available, it is not meant tobe all inclusive.
Aluminum Carbonate, basic
Capsules, equivalent to dried aluminum hydroxide gel 608 mg or aluminum hydroxide 500 mg
Basalgel® (Wyeth)
Suspension, equivalent to aluminum hydroxide 400 mg/5ml
Basalgel® (Wyeth)
Aluminum Hydroxide
Capsules, 475 mg; Alu-Cap® (Riker)500 mg; Dialume® (Armour)
Suspension320 mg/5 ml; Amphogel® (Wyeth-Ayerst)400 mg/5 ml; Aluminum Hydroxide Gel® (Roxane)600 mg/5 ml; Alternagel® (Stuart), Aluminum Hydroxide Concentrated® (Roxane)
Magnesium Hydroxide
Powder
Oral Suspension (Milk of Magnesia) ยป77.5 mg/gram
Aluminum Hydroxide and Magnesium Hydroxide
Suspension (Note: there are too many products and concentrations to list in this reference; arepresentative product is Maalox® Suspension (Rorer) which contains 225 mg aluminumhydroxide and 200 mg magnesium hydroxide per 5 ml.)
Other dosage forms that are available commercially include: tablets, chewable tablets, and aerosolfoam suspension.
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