Veterinary Drug Handbook (VDH) is the reference veterinarians turn to when they want an independent source of information on the drugs that are used in veterinary medicine today.

Doses - PROTAMINE SULFATE

Dogs & Cats: Dog Cat

For heparin overdosage:
a) Give 1 - 1.5 mg protamine sulfate to antagonize each mg (ยป100 units) of heparin viaslow IV injection. Reduce dose as time increases between heparin dose and start oftreatment (after 30 minutes give only 0.5 mg). (Bailey 1986a)
b) Administer 1 mg protamine for each 100 Units of heparin to be inactivated. Decreaseprotamine dose by 1/2 for every 30 minutes that have lapsed since heparin was administered (Author's note: This may be ineffective if heparin has been administered bydeep SQ injection). Give dose slowly IV, do not give at a rate faster than 50 mg over a10 minute period. (Adams 1988b)

Cattle: Cattle

For Bracken Fern (Pteridium sp.) poisoning:
a) In combination with whole blood (2.25-4.5L), 1 injection of 10 ml of 1% protaminesulfate IV. (Osweiler and Ruhr 1986)
Monitoring Parameters - See the Heparin monograph.
Client Information - Should only be used in a setting where adequate monitoring facilities areavailable.
Dosage Forms/Preparations/FDA Approval Status/Withholding Times - Veterinary-Approved Products: None

Human-Approved Products:

Protamine Sulfate Injection 10 mg/ml in 5 & 25 ml amps, and 5 & 25 ml vials; generic; (Rx)

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