TRIFLURIDINE (TRIFLUOROTHYMIDINE), SILVER SULFADIAZINE (OPHTHALMIC)

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TRIFLURIDINE (TRIFLUOROTHYMIDINE)

Indications/Pharmacology Trifluridine (trifluorothymidine; Viroptic®) is a pyrimidine nucleosideanalog. It is structurally related to 2-deoxythymidine, the natural precursor of DNA synthesis. Trifluridineis poorly absorbed by the cornea and is virostatic. Viroptic® interrupts viral... ↪ Read more

SILVER SULFADIAZINE (OPHTHALMIC)

Indications/Pharmacology Silver Sulfadiazine Cream is a broad spectrum agent which covers bacteria(gram positive and negative) and fungal agents. It has been used extensively in people suffering from skinburns. It is nontoxic to the skin, conjunctiva and cornea and has been used in the last several... ↪ Read more

MICONAZOLE (OPHTHALMIC)

Indications/Pharmacology Miconazole is a broad spectrum imidazole antifungal agent with someantibacterial activity. Miconazole will penetrate the intact corneal epithelium. Topical miconazole therapyhas been a favorite first choice agent for treatment of fungal keratitis in the horse by... ↪ Read more

NATAMYCIN (OPHTHALMIC)

Indications/Pharmacology Natamycin is a semisynthetic polyene antibiotic. Natamycin is poorly watersoluble and will not penetrate the intact corneal epithelium. Natamycin is the only antifungal agentapproved for use on the eye and the only commercially available eye drug for treatment of... ↪ Read more

ANTIBIOTIC & CORTICOSTEROID COMBINATIONS (OPHTHALMIC)

Indications/Pharmacology There are three basic categories of these products that are routinely used inveterinary medicine; antibiotic combinations with hydrocortisone, antibiotic combinations withdexamethasone, and individual antibiotics (e.g., gentamicin or chloramphenicol) with a... ↪ Read more

ANTIBIOTIC COMBINATIONS (OPHTHALMIC)

Indications/Pharmacology These combination products exhibit a broad-spectrum of activity and areconsidered the first choice for symptomatic treatment of conjunctivitis in dogs and for prophylactictreatment of small animals prior to or after eye surgery. These agents are also used prophylactically... ↪ Read more

TETRACYCLINE (OPHTHALMIC)

Indications/Pharmacology The tetracyclines are most useful in cats for the treatment Chlamydial and Mycoplasma conjunctivitis as well as nonspecific or symptomatic therapy for undiagnosed (causativeorganism not determined) conjunctivitis in cats. While its use in dogs and horses is questionable, it... ↪ Read more

GENTAMICIN (OPHTHALMIC), TOBRAMYCIN (OPHTHALMIC)

Indications/Pharmacology The aminoglycosides are excellent drugs for gram negative orstaphylococcal corneal infections. With frequent application, clinicians can establish corneal drug levelsfar in excess of MIC for most organisms without exceeding toxic systemic levels. Therefore, MIC reportsmay... ↪ Read more

CORTICOSTEROIDS, TOPICAL (OPHTHALMIC)

(see also Antibiotic & Corticosteroid Combinations) Indications/Dosages/Precautions - Topical corticosteroids are used to treat diseases of the eye involvingthe conjunctiva, sclera, cornea, and anterior chamber. Penetration of topically applied corticosteroids intothe eyelids is poor as is... ↪ Read more

CROMOLYN SODIUM (OPHTHALMIC)

Indications/Pharmacology Cromolyn sodium is a mast cell stabilizing agent that blocks release ofhistamine and slow-reacting substance of anaphylaxis from mast cells following antigen recognition. Similar to lodoxamine tromethamine, cromolyn sodium has no intrinsic vasoconstrictor, antihistaminic,... ↪ Read more

LODOXAMINE TROMETHAMINE (OPHTHALMIC)

Indications/Pharmacology Lodoxamine tromethamine is a mast cell stabilizer that inhibits Type Ihypersensitivity responses by preventing antigen mediated histamine release. Lodoxamine stabilizes mastcells by blocking calcium influx into the cell upon antigen recognition, thereby blocking... ↪ Read more

DICLOFENAC SODIUM (OPHTHALMIC)

Indications/Pharmacology Diclofenac sodium is a phenylacetic acid that inhibits cyclooxygenase, inhibiting prostaglandin synthesis. Diclofenac sodium topical solution reduces inflammation followingcataract extraction in people and counteracts photophobia in humans having refractive corneal surgery.... ↪ Read more